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RGS Domain
Known as:
RGS-Signaling Domain
, Regulators of G Protein Signaling Domain
Typically 120 amino acids long, the RGS (Regulator of G protein Signaling) Domain is found in over 20 human proteins, bind activated G-alpha subunits…
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National Institutes of Health
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Related topics
Related topics
18 relations
A-Kinase Anchor Protein 10, Mitochondrial
AXIN2 protein, human
Beta-Adrenergic Receptor Kinase 1
Beta-Adrenergic Receptor Kinase 2
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation.
Pu-Hyeon Cha
,
Yong-Hee Cho
,
+15 authors
Kang-Yell Choi
Nature Chemical Biology
2016
Corpus ID: 2084511
Both the Wnt/β-catenin and Ras pathways are aberrantly activated in most human colorectal cancers (CRCs) and interact…
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Highly Cited
2009
Highly Cited
2009
Translational control by RGS2
C. Nguyen
,
Hong Ming
,
+4 authors
P. Chidiac
Journal of Cell Biology
2009
Corpus ID: 14023871
A regulator of G protein signaling, RGS2, moonlights in protein synthesis control.
Highly Cited
2008
Highly Cited
2008
Structural diversity in the RGS domain and its interaction with heterotrimeric G protein α-subunits
M. Soundararajan
,
F. Willard
,
+11 authors
D. Siderovski
Proceedings of the National Academy of Sciences
2008
Corpus ID: 26287875
Regulator of G protein signaling (RGS) proteins accelerate GTP hydrolysis by Gα subunits and thus facilitate termination of…
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Highly Cited
2003
Highly Cited
2003
Gα12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF
Nobuchika Suzuki
,
Susumu Nakamura
,
H. Mano
,
T. Kozasa
Proceedings of the National Academy of Sciences…
2003
Corpus ID: 39129666
Heterotrimeric G proteins, G12 and G13, have been shown to transduce signals from G protein-coupled receptors to activate Rho…
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Review
2002
Review
2002
RGS2: a multifunctional regulator of G-protein signaling.
J. Kehrl
,
S. Sinnarajah
International Journal of Biochemistry and Cell…
2002
Corpus ID: 23197926
Highly Cited
2000
Highly Cited
2000
RGS domain in the amino-terminus of G protein-coupled receptor kinase 2 inhibits Gq-mediated signaling.
H. Usui
,
M. Nishiyama
,
+7 authors
S. Kimura
International Journal of Molecular Medicine
2000
Corpus ID: 37348268
We have previously shown that not only G protein-coupled receptor kinase (GRK) 2, but also a catalytically inactive Lys220Trp…
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Highly Cited
2000
Highly Cited
2000
Ca2+/Calmodulin Reverses Phosphatidylinositol 3,4,5-Trisphosphate-dependent Inhibition of Regulators of G Protein-signaling GTPase-activating Protein Activity*
S. Popov
,
U. M. Krishna
,
J. Falck
,
T. Wilkie
Journal of Biological Chemistry
2000
Corpus ID: 36599496
Regulators of G protein signaling (RGS proteins) are GTPase-activating proteins (GAPs) for Gi and/or Gq class G protein…
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Highly Cited
1999
Highly Cited
1999
Selective Regulation of Gαq/11 by an RGS Domain in the G Protein-coupled Receptor Kinase, GRK2*
C. Carman
,
J. Parent
,
+6 authors
T. Kozasa
Journal of Biological Chemistry
1999
Corpus ID: 22481886
G protein-coupled receptor kinases (GRKs) are well characterized regulators of G protein-coupled receptors, whereas regulators of…
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Highly Cited
1997
Highly Cited
1997
D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain.
L. Huang
,
K. Durick
,
J. Weiner
,
J. Chun
,
S. Taylor
Proceedings of the National Academy of Sciences…
1997
Corpus ID: 19234959
Subcellular localization directed by specific A kinase anchoring proteins (AKAPs) is a mechanism for compartmentalization of cAMP…
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Highly Cited
1997
Highly Cited
1997
The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro.
S. Popov
,
K. Yu
,
T. Kozasa
,
T. Wilkie
Proceedings of the National Academy of Sciences…
1997
Corpus ID: 25637589
Regulators of G protein signaling (RGS) proteins accelerate GTP hydrolysis by Gi but not by Gs class alpha-subunits. All RGS…
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