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RGS Domain

Known as: RGS-Signaling Domain, Regulators of G Protein Signaling Domain 
Typically 120 amino acids long, the RGS (Regulator of G protein Signaling) Domain is found in over 20 human proteins, bind activated G-alpha subunits… 
National Institutes of Health

Related topics

Related topics

18 relations
A-Kinase Anchor Protein 10, MitochondrialAXIN2 protein, humanBeta-Adrenergic Receptor Kinase 1Beta-Adrenergic Receptor Kinase 2

Papers overview

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Highly Cited
2016
Highly Cited
2016
Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation.
Both the Wnt/β-catenin and Ras pathways are aberrantly activated in most human colorectal cancers (CRCs) and interact… 
Highly Cited
2009
Highly Cited
2009
Translational control by RGS2
A regulator of G protein signaling, RGS2, moonlights in protein synthesis control. 
Highly Cited
2008
Highly Cited
2008
Structural diversity in the RGS domain and its interaction with heterotrimeric G protein α-subunits
Regulator of G protein signaling (RGS) proteins accelerate GTP hydrolysis by Gα subunits and thus facilitate termination of… 
Highly Cited
2003
Highly Cited
2003
Gα12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF
Heterotrimeric G proteins, G12 and G13, have been shown to transduce signals from G protein-coupled receptors to activate Rho… 
Review
2002
Review
2002
RGS2: a multifunctional regulator of G-protein signaling.
Highly Cited
2000
Highly Cited
2000
RGS domain in the amino-terminus of G protein-coupled receptor kinase 2 inhibits Gq-mediated signaling.
We have previously shown that not only G protein-coupled receptor kinase (GRK) 2, but also a catalytically inactive Lys220Trp… 
Highly Cited
2000
Highly Cited
2000
Ca2+/Calmodulin Reverses Phosphatidylinositol 3,4,5-Trisphosphate-dependent Inhibition of Regulators of G Protein-signaling GTPase-activating Protein Activity*
Regulators of G protein signaling (RGS proteins) are GTPase-activating proteins (GAPs) for Gi and/or Gq class G protein… 
Highly Cited
1999
Highly Cited
1999
Selective Regulation of Gαq/11 by an RGS Domain in the G Protein-coupled Receptor Kinase, GRK2*
G protein-coupled receptor kinases (GRKs) are well characterized regulators of G protein-coupled receptors, whereas regulators of… 
Highly Cited
1997
Highly Cited
1997
D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain.
Subcellular localization directed by specific A kinase anchoring proteins (AKAPs) is a mechanism for compartmentalization of cAMP… 
Highly Cited
1997
Highly Cited
1997
The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro.
Regulators of G protein signaling (RGS) proteins accelerate GTP hydrolysis by Gi but not by Gs class alpha-subunits. All RGS… 
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