RGS Domain

Known as: RGS-Signaling Domain, Regulators of G Protein Signaling Domain 
Typically 120 amino acids long, the RGS (Regulator of G protein Signaling) Domain is found in over 20 human proteins, bind activated G-alpha subunits… (More)
National Institutes of Health

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18 relations
A-Kinase Anchor Protein 10, MitochondrialAXIN2 protein, humanBeta-Adrenergic Receptor Kinase 1Beta-Adrenergic Receptor Kinase 2
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Papers overview

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2016
2016
Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation.
Both the Wnt/β-catenin and Ras pathways are aberrantly activated in most human colorectal cancers (CRCs) and interact… (More)
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2013
2013
The Ras-binding domain region of RGS14 regulates its functional interactions with heterotrimeric G proteins.
RGS14 is a 60 kDa protein that contains a regulator of G protein signaling (RGS) domain near its N-terminus, a central region… (More)
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2010
2010
14-3-3 protein interacts with and affects the structure of RGS domain of regulator of G protein signaling 3 (RGS3).
Regulator of G protein signaling (RGS) proteins function as GTPase-activating proteins (GAPs) for the alpha-subunit of… (More)
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2008
2008
Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Regulator of G protein signaling (RGS) proteins accelerate GTP hydrolysis by Galpha subunits and thus facilitate termination of… (More)
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2003
2003
Mild heat and proteotoxic stress promote unique subcellular trafficking and nucleolar accumulation of RGS6 and other RGS proteins. Role of the RGS domain in stress-induced trafficking of RGS proteins…
RGS proteins comprise a large family of proteins named for their ability to negatively regulate heterotrimeric G protein… (More)
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2003
2003
Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF.
Heterotrimeric G proteins, G12 and G13, have been shown to transduce signals from G protein-coupled receptors to activate Rho… (More)
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2001
2001
Differential capacities of the RGS1, RGS16 and RGS-GAIP regulators of G protein signaling to enhance alpha2A-adrenoreceptor agonist-stimulated GTPase activity of G(o1)alpha.
Recombinant RGS1, RGS16 and RGS-GAIP, but not RGS2, were able to substantially further stimulate the maximal GTPase activity of G… (More)
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Highly Cited
1999
Highly Cited
1999
Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2.
G protein-coupled receptor kinases (GRKs) are well characterized regulators of G protein-coupled receptors, whereas regulators of… (More)
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Highly Cited
1997
Highly Cited
1997
D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain.
Subcellular localization directed by specific A kinase anchoring proteins (AKAPs) is a mechanism for compartmentalization of cAMP… (More)
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1997
1997
The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro.
Regulators of G protein signaling (RGS) proteins accelerate GTP hydrolysis by Gi but not by Gs class alpha-subunits. All RGS… (More)
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