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Cellular Regulation of RGS Proteins: Modulators and Integrators of G Protein Signaling
Regulators of G protein signaling (RGS) and RGS-like proteins are a family (>30 members) of highly diverse, multifunctional signaling proteins that bind directly to activated Gα subunits. FamilyExpand
RGS2/G0S8 is a selective inhibitor of Gqα function
RGS (regulators of G protein signaling) proteins are GTPase activating proteins that inhibit signaling by heterotrimeric G proteins. All RGS proteins studied to date act on members of the Giα family,Expand
Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes.
Receptors for the serine protease thrombin and for lysophospholipids are coupled to G proteins and control a wide range of cellular functions, including mitogenesis. Activators of these receptors areExpand
Cell signalling diversity of the Gqalpha family of heterotrimeric G proteins.
Many receptors for neurotransmitters and hormones rely upon members of the Gqalpha family of heterotrimeric G proteins to exert their actions on target cells. Galpha subunits of the Gq class of GExpand
Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq.
The hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by phospholipase C yields the second messengers inositol 1,4,5-trisphosphate (InsP3) and 1,2-diacylglycerol. This activity is regulatedExpand
RGS2 Binds Directly and Selectively to the M1 Muscarinic Acetylcholine Receptor Third Intracellular Loop to Modulate Gq/11α Signaling*
RGS proteins serve as GTPase-activating proteins and/or effector antagonists to modulate Gα signaling events. In live cells, members of the B/R4 subfamily of RGS proteins selectively modulate GExpand
Cell signalling diversity of the Gqα family of heterotrimeric G proteins
Abstract Many receptors for neurotransmitters and hormones rely upon members of the Gqα family of heterotrimeric G proteins to exert their actions on target cells. Gα subunits of the Gq class of GExpand
RGS4 and GAIP are GTPase-activating proteins for Gq alpha and block activation of phospholipase C beta by gamma-thio-GTP-Gq alpha.
RGS proteins constitute a newly appreciated and large group of negative regulators of G protein signaling. Four members of the RGS family act as GTPase-activating proteins (GAPs) with apparentExpand
RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory
Learning and memory have been closely linked to strengthening of synaptic connections between neurons (i.e., synaptic plasticity) within the dentate gyrus (DG)–CA3–CA1 trisynaptic circuit of theExpand
Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases.
The capacities of the alpha subunits of pertussis toxin-sensitive guanine nucleotide-binding regulatory proteins (G proteins) to inhibit different isoforms of mammalian adenylyl cyclases wereExpand
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