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A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
TLDR
A relatively small set of miRNAs, many of which are ubiquitously expressed, account for most of the differences in miRNA profiles between cell lineages and tissues.
Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways
TLDR
Fuid flow increases inversin levels in ciliated tubular epithelial cells and seems to regulate this crucial switch between Wnt signaling pathways during renal development, implying that an inhibition of canonical Wnt behavior is required for normal renal development.
When cilia go bad: cilia defects and ciliopathies
TLDR
Cilia--tiny hair-like organelles attached to the cell surface--are located on almost all polarized cell types of the human body and have been adapted as versatile tools for various cellular functions, explaining why cilia-related disorders can affect many organ systems.
Nephrin and CD2AP Associate with Phosphoinositide 3-OH Kinase and Stimulate AKT-Dependent Signaling
TLDR
A novel role is revealed for the slit diaphragm proteins nephrin, CD2AP, and podocin and it is demonstrated that these three proteins, in addition to their structural functions, initiate PI3K/AKT-dependent signal transduction in glomerular podocytes.
Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination
TLDR
The interaction and colocalization in cilia of inversin, nephrocystin and β-tubulin connect pathogenetic aspects of NPHP to PKD, to primary cilia function and to left-right axis determination.
Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis
TLDR
The identification of NPHP3, encoding a novel 1,330-amino acid protein that interacts with nephrocystin, and it is shown that the mouse ortholog Nphp3 is expressed in the node, kidney tubules, retina, respiratory epithelium, liver, biliary tract and neural tissues.
The Carboxyl Terminus of Neph Family Members Binds to the PDZ Domain Protein Zonula Occludens-1*
TLDR
The data suggest that ZO-1 may organize Neph proteins and recruit signal transduction components to the slit diaphragm of podocytes, suggesting that phosphorylation may regulate this interaction.
Exome Capture Reveals ZNF423 and CEP164 Mutations, Linking Renal Ciliopathies to DNA Damage Response Signaling
TLDR
It is shown that knockdown of CEP164 or ZNF423 causes sensitivity to DNA damaging agents and that cep164 knockdown in zebrafish results in dysregulated DDR and an NPHP-RC phenotype, and these findings link degenerative diseases of the kidney and retina, disorders of increasing prevalence, to mechanisms of DDR.
Interaction with Podocin Facilitates Nephrin Signaling*
TLDR
It is demonstrated now that nephrin is a signaling molecule, which stimulates mitogen-activated protein kinases, which enhances Nephrin-induced signaling is greatly enhanced by podocin, which binds to the cytoplasmic tail of nephin.
Ischemic Preconditioning for Prevention of Contrast Medium–Induced Nephropathy: Randomized Pilot RenPro Trial (Renal Protection Trial)
TLDR
Remote ischemic preconditioning before contrast medium use prevents contrast medium–induced acute kidney injury in high-risk patients, and these findings merit a larger trial to establish the effect of remote ischeMIC preconditionsing on clinical outcomes.
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