AXIN2 protein, human

Known as: Axin-2, Axis inhibition protein 2, human, Conductin 
Axin-2 (843 aa, ~94 kDa) is encoded by the human AXIN2 gene. This protein is involved in downregulation of the Wnt signaling pathway.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Aberrant activation of canonical Wingless-type MMTV integration site family (Wnt) signaling is pathognomonic of colorectal… (More)
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Highly Cited
2006
Highly Cited
2006
Wnt and Notch signaling have long been established as strongly oncogenic in the mouse mammary gland. Aberrant expression of… (More)
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Highly Cited
2006
Highly Cited
2006
AbstractSelective tooth agenesis is the most common developmental abnormality of the human dentition. To date, this abnormality… (More)
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2006
2006
Accumulating evidence indicates that hyperactive Wnt signalling occurs in association with the development and progression of… (More)
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Highly Cited
2005
Highly Cited
2005
The Wnt signaling pathway has recently been demonstrated to play an important role in bone cell function. In previous studies… (More)
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Highly Cited
2004
Highly Cited
2004
Aberrant WNT pathway signaling is an early progression event in 90% of colorectal cancers. It occurs through mutations mainly of… (More)
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Highly Cited
2002
Highly Cited
2002
Activation of Wnt signaling through beta-catenin/TCF complexes is a key event in the development of various tumors, in particular… (More)
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Highly Cited
2002
Highly Cited
2002
Axin2/Conductin/Axil and its ortholog Axin are negative regulators of the Wnt signaling pathway, which promote the… (More)
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Highly Cited
2001
Highly Cited
2001
Genetic studies have identified mutations in key regulators of the Wnt/beta-catenin pathway in a variety of cancers, most… (More)
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Highly Cited
1998
Highly Cited
1998
Control of stability of beta-catenin is central in the wnt signaling pathway. Here, the protein conductin was found to form a… (More)
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