Beta-Adrenergic Receptor Kinase 1

Known as: Beta-ARK-1, EC 2.7.1.126, beta Adrenergic Receptor Kinase 1 
A ubiquitously expressed G-protein-coupled receptor kinase subtype that has specificity for the agonist-occupied form of BETA-ADRENERGIC RECEPTORS… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Phosphorylation of G protein-coupled receptors (GPCRs, which are also known as seven-transmembrane spanning receptors) by GPCR… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Myocardial G protein-coupled receptor kinase (GRK)2 is a critical regulator of cardiac beta-adrenergic receptor (betaAR… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Signaling through beta-arrestins is a recently appreciated mechanism used by seven-transmembrane receptors. Because G protein… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2005
2005
OBJECTIVES Desensitization and down-regulation of beta-adrenergic receptors (betaARs) are prominent features of heart failure… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Agonist-stimulated desensitization of the beta2-adrenergic receptor (beta2AR) is caused by both a potent cAMP-dependent protein… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Feedback inhibition is a fundamental principle in signal transduction allowing rapid adaptation to different stimuli. In… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Polymorphonuclear leukocytes (PMNs) are critical effector cells of the innate immune system that protect the host by migrating to… (More)
  • figure 1
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Cardiovascular regulation is tightly controlled by signaling through G protein-coupled receptors (GPCRs). beta-Adrenergic… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Agonist-dependent desensitization of the beta-adrenergic receptor requires translocation and activation of the beta-adrenergic… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Rapid desensitization of G protein-coupled receptors is mediated, at least in part, by their phosphorylation by the G protein… (More)
  • figure 1
  • figure 3
  • figure 2
  • table I
  • figure 5
Is this relevant?