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- Publications
- Influence
Hippocampal Long-Term Potentiation Is Reduced by Chronic Opiate Treatment and Can Be Restored by Re-Exposure to Opiates
- Lu Pu, Guo-Bin Bao, Nan-Jie Xu, L. Ma, G. Pei
- Medicine, Biology
- The Journal of Neuroscience
- 1 March 2002
Chronic exposure to opiates eventually leads to drug addiction, which is believed to involve maladaptive changes in brain function, but the underlying neuronal mechanisms remain primarily unknown.… Expand
Generation of neural progenitor cells by chemical cocktails and hypoxia
Neural progenitor cells (NPCs) can be induced from somatic cells by defined factors. Here we report that NPCs can be generated from mouse embryonic fibroblasts by a chemical cocktail, namely VCR (V,… Expand
Subcellular Localization of β-Arrestins Is Determined by Their Intact N Domain and the Nuclear Export Signal at the C Terminus*
- P. Wang, Y. Wu, X. Ge, L. Ma, G. Pei
- Biology, Medicine
- The Journal of Biological Chemistry
- 28 March 2003
β-Arrestin1 and β-arrestin2 play a key role in the regulation of G protein-coupled receptor-mediated signaling, whereas the subcellular distribution of β-arrestin1 and β-arrestin2 has been shown to… Expand
Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation.
Amyloid plaque is the hallmark and primary cause of Alzheimer disease. Mutations of presenilin-1, the gamma-secretase catalytic subunit, can affect amyloid-beta (Abeta) production and Alzheimer… Expand
β-Arrestin 2 Functions as a G-Protein-coupled Receptor-activated Regulator of Oncoprotein Mdm2*
- P. Wang, Hua Gao, +6 authors G. Pei
- Medicine, Biology
- The Journal of Biological Chemistry
- 21 February 2003
Oncoprotein Mdm2 is a master negative regulator of the tumor suppressor p53 and has been recently shown to regulate the ubiquitination of β-arrestin 2, an important adapter and scaffold in signaling… Expand
A Point Mutation That Confers Constitutive Activity to CXCR4 Reveals That T140 Is an Inverse Agonist and That AMD3100 and ALX40-4C Are Weak Partial Agonists*
- W. Zhang, J. Navenot, +8 authors S. Peiper
- Medicine, Biology
- The Journal of Biological Chemistry
- 5 July 2002
CXCR4 is a G protein-coupled receptor for stromal-derived factor 1 (SDF-1) that plays a critical role in leukocyte trafficking, metastasis of mammary carcinoma, and human immunodeficiency virus… Expand
E‐Cadherin‐Mediated Cell–Cell Contact Is Critical for Induced Pluripotent Stem Cell Generation
- Taotao Chen, D. Yuan, +7 authors G. Pei
- Biology, Medicine
- Stem cells
- 1 August 2010
The low efficiency of reprogramming and genomic integration of virus vectors obscure the potential application of induced pluripotent stem (iPS) cells; therefore, identification of chemicals and… Expand
Amyloid deposition and inflammation in APPswe/PS1dE9 mouse model of Alzheimer's disease.
- Lingfei Ruan, Zhoujun Kang, G. Pei, Y. Le
- Medicine
- Current Alzheimer research
- 2009
Alzheimer's disease (AD) is characterized by amyloid plaques and neurofibrillary tangles associated with chronic inflammation. APPswe/PS1dE9 is an AD mouse model bearing mutant transgenes of amyloid… Expand
Construction and dynamic test of a small-scale organic rankine cycle
The fundamentals of a newly constructed kW-scale Organic Rankine Cycle (ORC) system on the use of R123 were illustrated. A specially designed and manufactured turbine was innovatively applied to this… Expand
Activation of β2-adrenergic receptor stimulates γ-secretase activity and accelerates amyloid plaque formation
Amyloid plaque is the hallmark and primary cause of Alzheimer disease. Mutations of presenilin-1, the γ-secretase catalytic subunit, can affect amyloid-β (Aβ) production and Alzheimer disease… Expand