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Polyubiquitin chains: polymeric protein signals.
Solution Structure of the Proapoptotic Molecule BID A Structural Basis for Apoptotic Agonists and Antagonists
Diverse polyubiquitin interaction properties of ubiquitin-associated domains
- S. Raasi, R. Varadan, D. Fushman, C. Pickart
- Biology, MedicineNature Structural &Molecular Biology
- 10 July 2005
The polyubiquitin interaction properties of 30 UBA domains are surveyed, including 16 of 17 occurrences in budding yeast, and it is suggested that an ectopic UBA domain to alter the specificity of a deubiquitylating enzyme in a predictable manner is suggested.
Structural properties of polyubiquitin chains in solution.
Characterization of the overall and local dynamics of a protein with intermediate rotational anisotropy: Differentiating between conformational exchange and anisotropic diffusion in the B3 domain of…
The overall and backbone dynamics of the B3 domain of protein G is studied using 15N relaxation measurements and it is shown that the picture of local motions is markedly dependent on the model of overall tumbling.
The main-chain dynamics of the dynamin pleckstrin homology (PH) domain in solution: analysis of 15N relaxation with monomer/dimer equilibration.
The backbone dynamics of the pleckstrin homology (PH) domain from dynamin were studied by 15N NMR relaxation and steady state heteronuclear 15N [1H] nuclear Overhauser effect measurements, and by molecular dynamics simulations.
Identification of the binding site for acidic phospholipids on the pH domain of dynamin: implications for stimulation of GTPase activity.
- J. Zheng, S. Cahill, M. Lemmon, D. Fushman, J. Schlessinger, D. Cowburn
- Chemistry, MedicineJournal of molecular biology
- 12 January 1996
A rapid method for screening PH domain/ligand interactions that gives precise binding constants is described, and it is confirmed that PtdIns(4,5)P2 can bind to dynamin PH domain, although not in an aggregated state.
Structural determinants for selective recognition of a Lys48-linked polyubiquitin chain by a UBA domain.
Crystal structure and solution NMR studies of Lys48-linked tetraubiquitin at neutral pH.