M. Ascoli

Publications153
h-index47
Citations6,297
Highly Influential Citations142
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Characterization of several clonal lines of cultured Leydig tumor cells: gonadotropin receptors and steroidogenic responses.
Several clonal lines of cultured Leydig tumor cells have been established and characterized in terms of gonadotropin receptors and steroid production. Although freshly isolated cells derived from the… Expand
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The lutropin/choriogonadotropin receptor ... 4 years later.
A comparison of this review with the review on the LH/CG receptor that we published in this journal 4 yr ago (1) clearly shows that the field has advanced tremendously in this short period of time.… Expand
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GIPC Binds to the Human Lutropin Receptor (hLHR) through an Unusual PDZ Domain Binding Motif, and It Regulates the Sorting of the Internalized Human Choriogonadotropin and the Density of Cell Surface…
By using a yeast two-hybrid screen we identified GIPC (GAIP-interacting protein C terminus), a protein with a type I PDZ domain as a novel human lutropin receptor (hLHR) binding partner. Pull-down… Expand
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Mutations That Induce Constitutive Activation and Mutations That Impair Signal Transduction Modulate the Basal and/or Agonist-stimulated Internalization of the Lutropin/Choriogonadotropin Receptor*
Previous results from this laboratory suggested that the same active conformation of the lutropin/choriogonadotropin receptor (LHR) is involved in the stimulation of G proteins and in triggering the… Expand
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The lutropin/choriogonadotropin receptor-induced phosphorylation of the extracellular signal-regulated kinases in leydig cells is mediated by a protein kinase a-dependent activation of ras.
The pathways involved in activation of the ERK1/2 cascade in Leydig cells were examined in MA-10 cells expressing the recombinant human LH receptor (hLHR) and in primary cultures of rat Leydig cell… Expand
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Follitropin (FSH) and a phorbol ester stimulate the phosphorylation of the FSH receptor in intact cells.
Using a cell line stably transfected with the rat follitropin (FSH) receptor cDNA we demonstrate that the FSH receptor becomes phosphorylated when cells are exposed to FSH. Since binding of FSH to… Expand
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Ovulation involves the luteinizing hormone-dependent activation of G(q/11) in granulosa cells.
The LH receptor (LHR) activates several families of heterotrimeric G proteins, but only the activation of Gs and subsequent generation of cAMP are universally accepted as important mediators of LH… Expand
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Role of G protein-coupled receptor kinases on the agonist-induced phosphorylation and internalization of the follitropin receptor.
The experiments presented herein were designed to identify members of the G protein-coupled receptor kinase (GRK) family that participate in the agonist-induced phosphorylation and internalization of… Expand
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Immortalized Leydig Cell Lines as Models for Studying Leydig Cell Physiology
This chapter provides a brief overview of the properties of various immortalized Leydig cell lines and their usefulness in the study of Leydig cell physiology.
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Effect of activating and inactivating mutations on the phosphorylation and trafficking of the human lutropin/choriogonadotropin receptor.
The effects of several mutations of the human LH receptor (hLHR) on the phosphorylation, internalization, and turnover of the cell surface receptor were examined. Three gain-of-function mutations… Expand
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