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ADRBK1 wt Allele

Known as: BARK1, GRK2, Adrenergic, Beta, Receptor Kinase 1 wt Allele 
Human ADRBK1 wild-type allele is located within 11q13 and is approximately 20 kb in length. This allele, which encodes beta-adrenergic receptor… 
National Institutes of Health

Related topics

Related topics

10 relations
11q13Beta-Adrenergic Receptor Kinase 1G Protein-Coupled Receptor SignalingGPCR Signaling Pathway

Broader (1)

ADRBK1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization
High-efficacy opioids enhance receptor desensitization due to rapid and sustained GRK2/β-arrestin interactions. Controlling… 
Highly Cited
2015
Highly Cited
2015
Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2
Inhibiting a protein involved in insulin and adrenergic signaling may improve metabolic disorders. Counteracting the effects of a… 
Highly Cited
2013
Highly Cited
2013
The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist
Nebivolol, a third generation β-adrenoceptor (β-AR) antagonist (β-blocker), causes vasodilation by inducing nitric oxide (NO… 
Highly Cited
2012
Highly Cited
2012
The Chemokine Receptors CXCR1 and CXCR2 Couple to Distinct G Protein-Coupled Receptor Kinases To Mediate and Regulate Leukocyte Functions
The chemokine receptors, CXCR1 and CXCR2, couple to Gαi to induce leukocyte recruitment and activation at sites of inflammation… 
Review
2012
Review
2012
GRK2 inhibition in heart failure: something old, something new.
Despite significant advances in pharmacological and clinical treatment, heart failure (HF) remains the number one killer disease… 
Highly Cited
2011
Highly Cited
2011
GRK2-Dependent S1PR1 Desensitization Is Required for Lymphocytes to Overcome Their Attraction to Blood
A molecular mechanism that allows lymphocytes to migrate against a chemokine gradient is revealed. Lymphocytes egress from… 
Highly Cited
2009
Highly Cited
2009
G Protein-coupled Receptor Kinase-2 Constitutively Regulates D2 Dopamine Receptor Expression and Signaling Independently of Receptor Phosphorylation*
We investigated the regulatory effects of GRK2 on D2 dopamine receptor signaling and found that this kinase inhibits both… 
Review
2008
Review
2008
GPCR signalling in hypertension: role of GRKs.
Hypertension is a prevalent condition in the developed world and disease severity is directly correlated with additional… 
Highly Cited
1999
Highly Cited
1999
Selective regulation of G protein-coupled receptor-mediated signaling by G protein-coupled receptor kinase 2 in FRTL-5 cells: analysis of thyrotropin, alpha(1B)-adrenergic, and A(1) adenosine…
G protein-coupled receptor kinases (GRKs) play a key role in the process of receptor homologous desensitization. In the present… 
Highly Cited
1996
Highly Cited
1996
Identification of the G Protein-coupled Receptor Kinase Phosphorylation Sites in the Human β2-Adrenergic Receptor*
Rapid desensitization of G protein-coupled receptors is mediated, at least in part, by their phosphorylation by the G protein… 
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