• Publications
  • Influence
Identification of a serotonin/glutamate receptor complex implicated in psychosis
It is shown that the mGluR2 interacts through specific transmembrane helix domains with the 2AR, a member of an unrelated G-protein-coupled receptor family, to form functional complexes in brain cortex that may be involved in the altered cortical processes of schizophrenia. Expand
Heterotrimeric G‐proteins: a short history
The generation of chimeras between different α‐subunits defined the role of different sections of the primary/secondary sequence and crystal structures and cocrystals with interacting proteins have given detailed understanding of their molecular structure and basis of function. Expand
Presynaptic Control of Striatal Glutamatergic Neurotransmission by Adenosine A1–A2A Receptor Heteromers
It is demonstrated that heteromerization of adenosine A1 receptors and A2A receptors allowsAdenosine to exert a fine-tuning modulation of glutamatergic neurotransmission and that chronic caffeine treatment leads to modifications in the function of the A1R–A2AR heteromer that could underlie the strong tolerance to the psychomotor effects of caffeine. Expand
G-Protein–Coupled Receptor Mas Is a Physiological Antagonist of the Angiotensin II Type 1 Receptor
It is demonstrated that Mas can hetero-oligomerize with the AT1 receptor and by so doing inhibit the actions of angiotensin II, a novel demonstration that a G-protein–coupled receptor acts as a physiological antagonist of a previously characterized receptor. Expand
Receptor for the Pain Modulatory Neuropeptides FF and AF Is an Orphan G Protein-coupled Receptor*
expression of HLWAR77 was demonstrated in brain regions associated with opiate activity, consistent with the pain-modulating activity of these peptides, whereas the expression in adipose tissue suggests other physiological and pathophysiological activities for FMRF-amide neuropeptides. Expand
Bradykinin excites rat sympathetic neurons by inhibition of M current through a mechanism involving B2 receptors and Gαq/11
BK is the most potent M current inhibitor yet described in mammalian neurons, and BK inhibition of M current is mediated by a G protein pathway similar to that activated by muscarinic acetylcholine receptors. Expand
International Union of Pharmacology. LXXI. Free Fatty Acid Receptors FFA1, -2, and -3: Pharmacology and Pathophysiological Functions
A comprehensive overview of the current understanding of the pharmacology and physiological role of the G protein-coupled receptors activated by free fatty acids is provided. Expand
The chemokine receptor CCX‐CKR mediates effective scavenging of CCL19 in vitro
It is shown that both CCX‐CKR and CCR7 mediate rapid CCL19 internalisation upon initial chemokine exposure, and predicted that CCX-CKR scavenges extracellular chemokines in vivo to modify responses through C CR7, which is linked to the routes of endocytosis used by these receptors. Expand
G protein‐coupled receptor hetero‐dimerization: contribution to pharmacology and function
  • G. Milligan
  • Biology, Medicine
  • British journal of pharmacology
  • 1 September 2009
The concept that G protein‐coupled receptors (GPCRs) can form hetero‐dimers or hetero-oligomers continues to gain experimental support, but with the exception of the GABAB receptor and the sweet and umami taste receptors few reported examples meet all of the criteria needed to define distinct and physiologically relevant receptor species. Expand
G Protein–Coupled Receptor Oligomerization Revisited: Functional and Pharmacological Perspectives
The functional and pharmacological properties of GPCR oligomers are reviewed and some guidelines for the application of discrete direct screening and high-throughput screening approaches to the discovery of receptor-heteromer selective compounds are provided. Expand