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Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation
Phosphoinositide 3-kinase (PI3K) activity is crucial for leukocyte function, but the roles of the four receptor-activated isoforms are unclear. Mice lacking heterotrimeric guanine nucleotide-bindingExpand
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Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.
Phosphoinositide 3-kinase (PI3K) activity is crucial for leukocyte function, but the roles of the four receptor-activated isoforms are unclear. Mice lacking heterotrimeric guanine nucleotide-bindingExpand
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Trimeric G Protein-Dependent Frizzled Signaling in Drosophila
Frizzled (Fz) proteins are serpentine receptors that transduce critical cellular signals during development. Serpentine receptors usually signal to downstream effectors through an associated trimericExpand
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Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila
The lipid‐modified morphogens Wnt and Hedgehog diffuse poorly in isolation yet can spread over long distances in vivo, predicting existence of two distinct forms of these mophogens. The first isExpand
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Wnt3a stimulation elicits G-protein-coupled receptor properties of mammalian Frizzled proteins.
Receptors of the Fz (Frizzled) family initiate Wnt ligand-dependent signalling controlling multiple steps in organism development and carcinogenesis. Fz proteins possess seven transmembrane domains,Expand
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Targeting the Wnt pathways for therapies
The Wnt/β-catenin signaling pathway is crucial in animal development from sponges to humans. Its activity in the adulthood is less general, with exceptions having huge medical importance. Namely,Expand
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The trimeric G protein Go inflicts a double impact on axin in the Wnt/frizzled signaling pathway
The Wnt/Frizzled signaling pathway plays crucial roles in animal development and is deregulated in many cases of carcinogenesis. We and others have previously demonstrated that Frizzled proteinsExpand
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Reggies/flotillins interact with Rab11a and SNX4 at the tubulovesicular recycling compartment and function in transferrin receptor and E-cadherin trafficking
In this study reggie-1/flotillin-2 is identified as a component of the tubulovesicular sorting and recycling compartment, where it interacts with and controls the activity of Rab11a and SNX4.Expand
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Frizzled Proteins are bona fide G Protein-Coupled Receptors
Receptors of the Frizzled family initiate Wnt ligand-dependent signaling controllingmultiple steps in organism development and highly conserved in evolution [1]. Misactivation of the Wnt/FrizzledExpand
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A Direct and Functional Interaction Between Go and Rab5 During G Protein–Coupled Receptor Signaling
Regulation of a small GTPase by a heterotrimeric G protein determines the outcome of signaling from the receptor Frizzled. Internal Decisions Frizzled (Fz) proteins are receptors that trigger twoExpand
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