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RELA protein, human

Known as: Nuclear Factor Kappa-B Subunit 3, Transcription Factor NFKB3, NFkappaB p65 Subunit 
Transcription factor p65 (551 aa, ~60 kDa) is encoded by the human RELA gene. This protein is involved in the modulation of both signaling and gene… Expand
National Institutes of Health

Related topics

Related topics

37 relations
AKT Signaling PathwayATM Signaling PathwayAdipocytokine Signaling PathwayApoptosis
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Broader (1)

Transcription Factor RelA

Papers overview

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Highly Cited
2011
Highly Cited
2011
The RelA/SpoT Homolog (RSH) Superfamily: Distribution and Functional Evolution of ppGpp Synthetases and Hydrolases across the Tree of Life
RelA/SpoT Homologue (RSH) proteins, named for their sequence similarity to the RelA and SpoT enzymes of Escherichia coli… Expand
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Highly Cited
2010
Highly Cited
2010
NF-κB RelA Subunit Is Crucial for Early IFN-β Expression and Resistance to RNA Virus Replication
RNA virus infection results in expression of type 1 IFNs, especially IFN-α/β, which play a crucial role in host antivirus… Expand
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Highly Cited
2010
Highly Cited
2010
Oncoproteomic Analysis Reveals Co-Upregulation of RELA and STAT5 in Carboplatin Resistant Ovarian Carcinoma
Background Ovarian cancer is one of the most lethal types of female malignancy. Although most patients are initially responsive… Expand
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Highly Cited
2008
Highly Cited
2008
RelA Ser276 Phosphorylation Is Required for Activation of a Subset of NF-κB-Dependent Genes by Recruiting Cyclin-Dependent Kinase 9/Cyclin T1 Complexes
ABSTRACT NF-κB plays a central role in cytokine-inducible inflammatory gene expression. Previously we empirically determined the… Expand
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Highly Cited
2007
Highly Cited
2007
COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase.
NF-kappaB is a pleiotropic transcription factor involved in multiple processes, including inflammation and oncogenesis. We have… Expand
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Highly Cited
2004
Highly Cited
2004
Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-γ and RelA
The human gut microflora is important in regulating host inflammatory responses and in maintaining immune homeostasis. The… Expand
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Highly Cited
2004
Highly Cited
2004
Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B.
With the emerging role of NF-kappa B in cancer it is important that its responses to stimuli relevant to tumor progression and… Expand
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Highly Cited
2003
Highly Cited
2003
RelB Forms Transcriptionally Inactive Complexes with RelA/p65*
RelB is an unusual member of the NF-κB transcription factor family that acts as both a transcriptional activator as well as a… Expand
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Highly Cited
2002
Highly Cited
2002
Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.
The nuclear function of the heterodimeric NF-kappaB transcription factor is regulated in part through reversible acetylation of… Expand
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Highly Cited
2002
Highly Cited
2002
Dissection of the mechanism for the stringent factor RelA.
During conditions of nutrient deprivation, ribosomes are blocked by uncharged tRNA at the A site. The stringent factor RelA binds… Expand
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