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RELA protein, human

Known as: Nuclear Factor Kappa-B Subunit 3, Transcription Factor NFKB3, NFkappaB p65 Subunit 
Transcription factor p65 (551 aa, ~60 kDa) is encoded by the human RELA gene. This protein is involved in the modulation of both signaling and gene… Expand
National Institutes of Health

Related topics

Related topics

37 relations
AKT Signaling PathwayATM Signaling PathwayAdipocytokine Signaling PathwayApoptosis
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Broader (1)

Transcription Factor RelA

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
The RelA/SpoT Homolog (RSH) Superfamily: Distribution and Functional Evolution of ppGpp Synthetases and Hydrolases across the Tree of Life
RelA/SpoT Homologue (RSH) proteins, named for their sequence similarity to the RelA and SpoT enzymes of Escherichia coli… Expand
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Highly Cited
2011
Highly Cited
2011
Single-molecule investigations of the stringent response machinery in living bacterial cells
The RelA-mediated stringent response is at the heart of bacterial adaptation to starvation and stress, playing a major role in… Expand
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Highly Cited
2008
Highly Cited
2008
RelA Ser276 Phosphorylation Is Required for Activation of a Subset of NF-κB-Dependent Genes by Recruiting Cyclin-Dependent Kinase 9/Cyclin T1 Complexes
ABSTRACT NF-κB plays a central role in cytokine-inducible inflammatory gene expression. Previously we empirically determined the… Expand
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Highly Cited
2007
Highly Cited
2007
COMMD1 promotes the ubiquitination of NF‐κB subunits through a cullin‐containing ubiquitin ligase
NF‐κB is a pleiotropic transcription factor involved in multiple processes, including inflammation and oncogenesis. We have… Expand
Review
2006
Review
2006
Roles for NF-kappaB in nerve cell survival, plasticity, and disease.
Here we review evidence of roles for NF-kappaB in the regulation of developmental and synaptic plasticity, and cell survival in… Expand
Highly Cited
2004
Highly Cited
2004
Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-γ and RelA
The human gut microflora is important in regulating host inflammatory responses and in maintaining immune homeostasis. The… Expand
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Highly Cited
2002
Highly Cited
2002
Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF‐κB
The nuclear function of the heterodimeric NF‐κB transcription factor is regulated in part through reversible acetylation of its… Expand
Highly Cited
2002
Highly Cited
2002
Dissection of the mechanism for the stringent factor RelA.
During conditions of nutrient deprivation, ribosomes are blocked by uncharged tRNA at the A site. The stringent factor RelA binds… Expand
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Highly Cited
1996
Highly Cited
1996
Mutual Transcriptional Interference between RelA and Androgen Receptor*
Cross-modulation between androgen receptor (AR) and NF-κB/Rel proteins was studied using various androgen- and NF-κB-regulated… Expand
Highly Cited
1994
Highly Cited
1994
An interaction between the DNA-binding domains of RelA(p65) and Sp1 mediates human immunodeficiency virus gene activation.
Induction of human immunodeficiency virus type 1 (HIV-1) gene expression in stimulated T cells has been attributed to the… Expand
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