RELA protein, human

Known as: Nuclear Factor Kappa-B Subunit 3, Transcription Factor NFKB3, NFkappaB p65 Subunit 
Transcription factor p65 (551 aa, ~60 kDa) is encoded by the human RELA gene. This protein is involved in the modulation of both signaling and gene… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1977-2018
0102019772018

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36 relations
AKT Signaling PathwayATM Signaling PathwayAdipocytokine Signaling PathwayApoptosis
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Broader (1)

Transcription Factor RelA

Related mentions per year

Related mentions per year

1936-2019
19401960198020002020
RELA protein, human
Apoptosis
Cell Nucleus
Signal Transduction
Transcriptional Regulation
NF-kappa B

Papers overview

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Highly Cited
2005
Highly Cited
2005
NF-kappaB RelA phosphorylation regulates RelA acetylation.
The nuclear functions of NF-kappaB p50/RelA heterodimers are regulated in part by posttranslational modifications of its RelA… (More)
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Highly Cited
2004
Highly Cited
2004
Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-γ and RelA
The human gut microflora is important in regulating host inflammatory responses and in maintaining immune homeostasis. The… (More)
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Highly Cited
2004
Highly Cited
2004
Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B.
With the emerging role of NF-kappa B in cancer it is important that its responses to stimuli relevant to tumor progression and… (More)
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Highly Cited
2004
Highly Cited
2004
Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers.
IkappaB Kinase (IKK)alpha is required for activation of an alternative NF-kappaB signaling pathway based on processing of the NF… (More)
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Highly Cited
2003
Highly Cited
2003
TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation.
Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a member of the TNF superfamily that has been shown to… (More)
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Highly Cited
2003
Highly Cited
2003
Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation.
The activation of the transcription factor NF-kappaB is central to the control of the cellular response triggered by many stimuli… (More)
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Highly Cited
2002
Highly Cited
2002
Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.
The nuclear function of the heterodimeric NF-kappaB transcription factor is regulated in part through reversible acetylation of… (More)
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Highly Cited
2002
Highly Cited
2002
Dissection of the mechanism for the stringent factor RelA.
During conditions of nutrient deprivation, ribosomes are blocked by uncharged tRNA at the A site. The stringent factor RelA binds… (More)
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Highly Cited
2001
Highly Cited
2001
Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment.
NF-kappaB binding sites are present in the promoter regions of many acute phase and inflammatory response genes, suggesting that… (More)
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Highly Cited
1994
Highly Cited
1994
An interaction between the DNA-binding domains of RelA(p65) and Sp1 mediates human immunodeficiency virus gene activation.
Induction of human immunodeficiency virus type 1 (HIV-1) gene expression in stimulated T cells has been attributed to the… (More)
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