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RELA protein, human

Known as: Nuclear Factor Kappa-B Subunit 3, Transcription Factor NFKB3, NFkappaB p65 Subunit 
Transcription factor p65 (551 aa, ~60 kDa) is encoded by the human RELA gene. This protein is involved in the modulation of both signaling and gene… 
National Institutes of Health

Related topics

Related topics

37 relations
AKT Signaling PathwayATM Signaling PathwayAdipocytokine Signaling PathwayApoptosis

Broader (1)

Transcription Factor RelA

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Association of HTLV Tax proteins with TAK1-binding protein 2 and RelA in calreticulin-containing cytoplasmic structures participates in Tax-mediated NF-κB activation.
2010
2010
Direct inhibition of elastase activity by indole-3-carbinol triggers a CD40-TRAF regulatory cascade that disrupts NF-kappaB transcriptional activity in human breast cancer cells.
Treatment of highly tumorigenic MDA-MB-231 human breast cancer cells with indole-3-carbinol (I3C) directly inhibited the… 
2008
2008
XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2.
2004
2004
1alpha,25(OH)(2)D(3) regulates NF-kappaB DNA binding activity in cultured normal human keratinocytes through an increase in IkappaBalpha expression.
NF-kappaB is a dimeric transcription factor which regulates transcription of a number of different genes including IL-8 and p53… 
2002
2002
RelA suppresses the Wnt/beta-catenin pathway without exerting trans-acting transcriptional ability.
Several cellular signaling systems exhibit cross talk. Cross talk seems to play an important role in modifying signal effects. In… 
Highly Cited
2000
Highly Cited
2000
Signal-dependent and -independent degradation of free and NF-kappa B-bound IkappaBalpha.
A family of inhibitory IkappaB molecules regulates the activation of the transcription factor NF-kappaB. One member of the… 
Highly Cited
1999
Highly Cited
1999
Interaction of the Human NF-κB p52 Transcription Factor with DNA-PNA Hybrids Mimicking the NF-κB Binding Sites of the Human Immunodeficiency Virus Type 1 Promoter*
We determined whether peptide nucleic acids (PNAs) are able to interact with NF-κB p52 transcription factor. The binding of NF-κB… 
Highly Cited
1995
Highly Cited
1995
Overexpression of RelA in transgenic mouse thymocytes: specific increase in levels of the inhibitor protein I kappa B alpha
RelA (p65) is one of the strongest activators of the Rel/NF-kappa B family. As a first step to elucidate the mechanisms that… 
Highly Cited
1995
Highly Cited
1995
Tumor necrosis factor-alpha-dependent activation of a RelA homodimer in astrocytes. Increased phosphorylation of RelA and MAD-3 precede activation of RelA.
Rel proteins are important intracellular mediators of cytokine-induced signal transduction. To understand how cytokines affect… 
1977
1977
Cyclic AMP can replace the relA-dependent requirement for derepression of acetohydroxy acid synthase in E. coli K-12
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