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AKT Signaling Pathway

Many cell-surface receptors induce production of second messengers like PIP3, phosphatidylinositol 3,4,5-trisphosphate, that convey signals to the… 
National Institutes of Health

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AKT1 wt AlleleBAD wt AlleleBad proteinCASP9 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Carbachol alleviates myocardial injury in septic rats through PI3K/AKT signaling pathway.
OBJECTIVE To explore the effect of carbachol on myocardial injury in septic rats, and to further study its influence on the… 
2019
2019
NKAP plays an oncogenic function partly through AKT signaling pathway in hepatocellular carcinoma.
NF-kB activating protein (NKAP) is a highly conserved protein involved in transcriptional repression, immune cell development… 
2018
2018
LINC00673 silencing inhibits cell migration and invasion by suppressing PI3K/AKT signaling in glioma
LINC00673 is an oncogene that plays a key role in various cancer types. However, the role of LINC00673 in glioma remains unclear… 
2016
2016
Anti-Diabetic Action of Cydonia oblonga Seed Extract: Improvement ofGlucose Metabolism via Activation of PI3K/AKT Signaling Pathway
Context: Diabetes mellitus is one of the most common metabolic syndromes characterized by hyperglycemia. Cydonia oblonga Miller… 
2016
2016
Heme oxygenase 1 induction protects myocardiac cells against hypoxia/reoxygenation-induced apoptosis : The role of JNK/c-Jun/Caspase-3 inhibition and Akt signaling enhancement.
BACKGROUND Although recent studies have found that heme oxygenase (HO)-1 plays an important role in myocardiac cell survival, the… 
2016
2016
Heme oxygenase 1 induction protects myocardiac cells against hypoxia/reoxygenation-induced apoptosis
BackgroundAlthough recent studies have found that heme oxygenase (HO)-1 plays an important role in myocardiac cell survival, the… 
2011
2011
A High-Content Screen Identifies Inhibitors of Nuclear Export of Forkhead Transcription Factors
Class O forkhead box (FOXO) transcription factors are downstream targets of the PI3K/AKT signaling pathway, which is upregulated… 
2011
2011
[Effect of celastrol on Akt signaling pathway and apoptosis of leukemic K562 cell line].
OBJECTIVE To research the effect and route of celastrol on Akt signaling pathway of human leukemia cell line K562 apoptosis… 
2010
2010
Prox1 Facilitates Transfected CHO Cell Proliferation through Activation of the AKT Signaling Pathway
The homeobox transcription factor Prox1 plays an important role in the development of many embryonic organs. Previous studies… 
Highly Cited
2002
Highly Cited
2002
Insulin-like Growth Factor-1-mediated AKT Activation Postpones the Onset of Ultraviolet B-induced Apoptosis, Providing More Time for Cyclobutane Thymine Dimer Removal in Primary Human Keratinocytes*
Insulin-like growth factor-1 (IGF-1) acts as a potent survival factor in numerous cell lines, primarily through activation of the… 
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