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AKT Signaling Pathway

Many cell-surface receptors induce production of second messengers like PIP3, phosphatidylinositol 3,4,5-trisphosphate, that convey signals to the… 
National Institutes of Health

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AKT1 wt AlleleBAD wt AlleleBad proteinCASP9 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
PSMC6 promotes osteoblast apoptosis through inhibiting PI3K/AKT signaling pathway activation in ovariectomy‐induced osteoporosis mouse model
There is now increasing evidence which suggests a key role for osteoblast apoptosis in the pathogenesis of postmenopausal… 
2019
2019
LEM domain containing 1 promotes proliferation via activating the PI3K/Akt signaling pathway in gastric cancer
Gastric cancer (GC) is one of the most common cancers worldwide and has especially high morbidity and mortality in China. LEM… 
Highly Cited
2018
Highly Cited
2018
Effects of Fibronectin 1 on Cell Proliferation, Senescence and Apoptosis of Human Glioma Cells Through the PI3K/AKT Signaling Pathway
Background/Aims: The current study aimed to investigate the role by which fibronectin 1 (FN1) influences the cell cycle… 
2018
2018
Matrine reversed multidrug resistance of breast cancer MCF‐7/ADR cells through PI3K/AKT signaling pathway
Matrine is an alkaloid extracted from a Chinese herb Sophora flavescens Ait, and has been used clinically for breast cancer with… 
Highly Cited
2018
Highly Cited
2018
CircIBTK inhibits DNA demethylation and activation of AKT signaling pathway via miR-29b in peripheral blood mononuclear cells in systemic lupus erythematosus
BackgroundSystemic lupus erythematosus (SLE) is a chronic and incurable autoimmune disease involving the dysfunction of… 
2018
2018
MiR-124 affects the apoptosis of brain vascular endothelial cells and ROS production through regulating PI3K/AKT signaling pathway.
OBJECTIVE The apoptosis of vascular endothelial cells (VEC) is related to ischemic stroke. Phosphatidylinositol-3 kinase (PI3K… 
2018
2018
L-butyl phthalein improves neural function of vascular dementia mice by regulating the PI3K/AKT signaling pathway.
OBJECTIVE L-3-n-butylphthalide (L-NBP) is a type of anti-ischemic cranial nerve protective drug that may act on vascular dementia… 
2017
2017
MicroRNA-302b-3p Suppresses Cell Proliferation Through AKT Pathway by Targeting IGF-1R in Human Gastric Cancer
Background/Aims: MiR-302b is a major microRNA found in human embryonic stem cells and induced pluripotent stem cells. However… 
Highly Cited
2009
Highly Cited
2009
p66Shc Links &agr;1-Adrenergic Receptors to a Reactive Oxygen Species–Dependent AKT-FOXO3A Phosphorylation Pathway in Cardiomyocytes
p66Shc is an adapter protein that is induced by hypertrophic stimuli and has been implicated as a major regulator of reactive… 
Highly Cited
2002
Highly Cited
2002
Insulin-like Growth Factor-1-mediated AKT Activation Postpones the Onset of Ultraviolet B-induced Apoptosis, Providing More Time for Cyclobutane Thymine Dimer Removal in Primary Human Keratinocytes*
Insulin-like growth factor-1 (IGF-1) acts as a potent survival factor in numerous cell lines, primarily through activation of the… 
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