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Bad protein

Known as: BCL2-Binding Protein, Bcl-XL/Bcl-2-Associated Death Promoter, BCL2-Antagonist of Cell Death 
A pro-apoptotic protein and member of the Bcl-2 protein family that is regulated by PHOSPHORYLATION. Unphosphorylated Bad protein inhibits the… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Circumvention of apoptotic machinery is one of the distinctive properties of carcinogenesis. Extensively established key… Expand
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Review
2017
Review
2017
Inflammatory bowel disease (IBD) is a multifactorial disease. A breach in the mucosal barrier, otherwise known as “leaky gut,” is… Expand
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Review
2004
Review
2004
Resveratrol, trans-3,5,4'-trihydroxystilbene, was first isolated in 1940 as a constituent of the roots of white hellebore… Expand
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Highly Cited
1999
Highly Cited
1999
The Ca2+-activated protein phosphatase calcineurin induces apoptosis, but the mechanism is unknown. Calcineurin was found to… Expand
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Highly Cited
1999
Highly Cited
1999
Signaling pathways between cell surface receptors and the BCL-2 family of proteins regulate cell death. Survival factors induce… Expand
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Highly Cited
1997
Highly Cited
1997
Growth factors can promote cell survival by activating the phosphatidylinositide-3'-OH kinase and its downstream target, the… Expand
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Highly Cited
1997
Highly Cited
1997
BAD is a distant member of the Bcl-2 family that promotes cell death. Phosphorylation of BAD prevents this. BAD phosphorylation… Expand
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Highly Cited
1996
Highly Cited
1996
Extracellular survival factors alter a cell's susceptibility to apoptosis, often through posttranslational mechanisms. However… Expand
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Highly Cited
1996
Highly Cited
1996
THE Bcl-2 family of proteins regulate programmed cell death by an unknown mechanism1. Here we describe the crystal and solution… Expand
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Highly Cited
1995
Highly Cited
1995
To extend the mammalian cell death pathway, we screened for further Bcl-2 interacting proteins. Both yeast two-hybrid screening… Expand
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