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The lipid droplet is an important organelle for hepatitis C virus production
A novel function of LDs is revealed in the assembly of infectious HCV and a new perspective on how viruses usurp cellular functions is provided.
Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis.
The nucleotide sequence of the Japanese type of hepatitis C virus (HCV-J) genome, consisting of 9413 nucleotides, was determined by analyses of cDNA clones from plasma specimens from Japanese
Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues
Analysis of miRNA expression profiles in hepatocellular carcinoma and adjacent non-tumorous tissue specimens may help clarify the molecular mechanisms involved in the progression of liver disease, potentially serving as a diagnostic tool of HCC.
Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus
Gene products of hepatitis C virus (HCV), a possible major causative agent of posttransfusion non-A, non-B hepatitis, are considered to be produced from a precursor polyprotein via proteolytic
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125
It is found that RIG-I undergoes proteasomal degradation after conjugation to ubiquitin by RNF125, which constitutes a negative regulatory loop circuit for IFN production.
Maintenance of self‐renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b
It is shown that undifferentiated embryonic stem (ES) cells can maintain stem cell properties and chromosomal stability in the absence of CpG methylation and C pG DNA methyltransferases.
Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis.
Analysis of processed proteins translated from a series of truncated forms of the cDNA construct as well as determination of amino- terminal amino acid sequences of gp35 and gp70 indicated that these four products are arranged from the amino-terminal end of the polyprotein precursor in the order: NH2-p22-gp35-gp70-p19.
Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes
The immunosuppressant cyclosporin A (CsA) was found to have a suppressive effect on the HCV replicon RNA level and HCV protein expression in these cells.
Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus.
By using a plasmid-based transient protein expression system in cultured cells and an in vitro transcription/translation system, we analyzed the proteolytic processing of the putative nonstructural