K. Shimotohno

Publications447
h-index81
Citations27,685
Highly Influential Citations1,113
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The lipid droplet is an important organelle for hepatitis C virus production
TLDR
A novel function of LDs is revealed in the assembly of infectious HCV and a new perspective on how viruses usurp cellular functions is provided.
View on Nature
Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis.
The nucleotide sequence of the Japanese type of hepatitis C virus (HCV-J) genome, consisting of 9413 nucleotides, was determined by analyses of cDNA clones from plasma specimens from Japanese…
View on PubMed
Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues
TLDR
Analysis of miRNA expression profiles in hepatocellular carcinoma and adjacent non-tumorous tissue specimens may help clarify the molecular mechanisms involved in the progression of liver disease, potentially serving as a diagnostic tool of HCC.
View on Nature
Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus
Gene products of hepatitis C virus (HCV), a possible major causative agent of posttransfusion non-A, non-B hepatitis, are considered to be produced from a precursor polyprotein via proteolytic…
View on ASMUSA
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125
TLDR
It is found that RIG-I undergoes proteasomal degradation after conjugation to ubiquitin by RNF125, which constitutes a negative regulatory loop circuit for IFN production.
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Maintenance of self‐renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b
TLDR
It is shown that undifferentiated embryonic stem (ES) cells can maintain stem cell properties and chromosomal stability in the absence of CpG methylation and C pG DNA methyltransferases.
View on Wiley
Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase.
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Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis.
TLDR
Analysis of processed proteins translated from a series of truncated forms of the cDNA construct as well as determination of amino- terminal amino acid sequences of gp35 and gp70 indicated that these four products are arranged from the amino-terminal end of the polyprotein precursor in the order: NH2-p22-gp35-gp70-p19.
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Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes
TLDR
The immunosuppressant cyclosporin A (CsA) was found to have a suppressive effect on the HCV replicon RNA level and HCV protein expression in these cells.
View on Wiley
Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus.
By using a plasmid-based transient protein expression system in cultured cells and an in vitro transcription/translation system, we analyzed the proteolytic processing of the putative nonstructural…
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