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In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector
The ability of HIV-based viral vectors to deliver genes in vivo into nondividing cells could increase the applicability of retroviral vectors in human gene therapy. Expand
NF-kappaB regulation in the immune system.
The role of NF-kappaB proteins as potential therapeutic targets in clinical applications and their role in the immune system and inflammatory diseases are discussed. Expand
NF-κB regulation in the immune system
The role of NF-κB proteins as potential therapeutic targets in clinical applications and their role in the immune system and inflammatory diseases are discussed. Expand
Suppression of TNF-α-Induced Apoptosis by NF-κB
- D. V. Van Antwerp, Seamus J. Martin, T. Kafri, D. Green, I. Verma
- Biology, Chemistry
- 1 November 1996
The sensitivity and kinetics of TNF-α-induced apoptosis are shown to be enhanced in a number of cell types expressing a dominant-negative IκB α (IκBαM). Expand
Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.
Suppression of TNF-alpha-induced apoptosis by NF-kappaB.
The sensitivity and kinetics of TNF-alpha-induced apoptosis are shown to be enhanced in a number of cell types expressing a dominant-negative Ikappa Balpha (IkappaBalphaM). Expand
Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector.
- L. Naldini, U. Blömer, F. Gage, D. Trono, I. Verma
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 15 October 1996
Development of clinically acceptable derivatives of the lentiviral vector may enable the sustained delivery of significant amounts of a therapeutic gene product in a wide variety of somatic tissues. Expand
Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene
Results show that IKK2 is essential for mouse development and cannot be substituted with IKK1, another component of the IKK complex. Expand
BRCA1 tumor suppression occurs via heterochromatin mediated silencing
It is proposed that the role of BRCA1 in maintaining global heterochromatin integrity accounts for many of its tumour suppressor functions. Expand
Development of a Self-Inactivating Lentivirus Vector
- H. Miyoshi, U. Blömer, Masayo Takahashi, F. Gage, I. Verma
- Medicine, Biology
- Journal of Virology
- 1 October 1998
Injection of viruses into the rat brain showed that a SIN vector containing the green fluorescent protein gene under the control of the internal CMV promoter transduced neurons as efficiently as a wild-type vector, indicating that the HIV-1 LTR promoter is transcriptionally active in neurons even in the absence of Tat. Expand