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Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis
TLDR
Data from a PCR-based technique and in situ hybridization revealed that while c-jun was induced in most neurons, c-fos induction was restricted to neurons undergoing chromatin condensation, a hallmark of apoptosis, and these data may outline a genetic program responsible for neuronal programmed cell death.
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Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins.
TLDR
A novel signaling pathway activated by the Rho proteins that may be responsible for their biological activities, including cytoskeleton organization, transformation, apoptosis, and metastasis is reported.
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Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse
TLDR
The demonstration that neuromeres are domains of gene expression provides molecular evidence for the segmentation of the CNS.
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Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites
TLDR
It was shown that the staining patterns of the replicon clusters and their order of appearance throughout the S phase are identical to those observed for cyclin, demonstrating that cyclin is tightly associated to the sites of DNA replication and that it must have a fundamental role in DNA synthesis in eukaryotic cells.
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Induction of c-fos gene and protein by growth factors precedes activation of c-myc
Stimulation of fibroblasts with serum or purified growth factors leads to a dramatic induction of expression of both c-fos mRNA and protein within a few minutes, followed by activation of c-myc. This…
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Cyclin/PCNA is the auxiliary protein of DNA polymerase-δ
TLDR
Cyclin and the auxiliary protein of DNA polymerase-δ are identical, and it is reported here that these two are identical.
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Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family
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Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2.
TLDR
A new mouse osteopetrotic mutant is defined and NF-kappaB proteins in bone development are implicated, raising new directions in the treatment of bone disorders and suggesting redundant functions of NF- kappaB1 andNF-kappB2 proteins in the development of this cell lineage.
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Nuclear Factor (NF)-κB2 (p100/p52) Is Required for Normal Splenic Microarchitecture and B Cell–mediated Immune Responses
TLDR
Findings indicate an important role of NF-κB2 in the maintenance of the peripheral B cell population, humoral responses, and normal spleen architecture.
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Controlled recruitment of monocytes and macrophages to specific organs through transgenic expression of monocyte chemoattractant protein-1.
TLDR
The mononuclear cell infiltrate in the brain can be significantly amplified by LPS treatment, suggesting that the recruitment properties of MCP-1 can be potentiated by additional factors.
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