Purinergic P1 Receptor Antagonists
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A 2A adenosine receptor antagonists usually have bi- or tricyclic N aromatic systems with varying substitution patterns to… Expand Ever since the discovery of the hypotensive and bradycardiac effects of adenosine, adenosine receptors continue to represent… Expand Memory loss in humans begins early in adult life and progresses thereafter. It is not known whether these losses reflect the… Expand Caffeine, an adenosine A1, A2A, and A2B receptor antagonist, is frequently used as an adjuvant analgesic in combination with… Expand OBJECTIVE
Weekly low-dose methotrexate (MTX) remains the mainstay of second-line therapy for rheumatoid arthritis (RA). We have… Expand 3,5-Diacyl-2,4-dialkyl-6-phenylpyridine derivatives have been found to be selective antagonists at both human and rat A3… Expand This study determined the levels of adenosine in the renal medullary interstitium using microdialysis and fluorescence HPLC… Expand New A2A adenosine receptor antagonists in the series of pyrazolo[4, 3-e]-1,2,4-triazolo[1,5-c]pyrimidines, bearing oxygenated… Expand The effects of nonselective (theophylline), A1-(DPCPX) or A2A-selective (SCH 58261) adenosine receptor antagonists administered… Expand Cerebral ischemia of 5 min duration was induced in unanesthetized Mongolian gerbils by bilateral occlusion of the carotid… Expand