Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat adjuvant arthritis.

@article{Montesinos2000ReversalOT,
  title={Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat adjuvant arthritis.},
  author={M. Montesinos and J. S. Yap and A. Desai and I. Posadas and C. McCrary and B. Cronstein},
  journal={Arthritis and rheumatism},
  year={2000},
  volume={43 3},
  pages={
          656-63
        }
}
OBJECTIVE Weekly low-dose methotrexate (MTX) remains the mainstay of second-line therapy for rheumatoid arthritis (RA). We have previously reported that adenosine, acting at specific receptors on inflammatory cells, mediates the antiinflammatory effects of MTX in both in vitro and in vivo models of acute inflammation, but the mechanism by which MTX suppresses the chronic inflammation of arthritis remains controversial. The present study was undertaken to further investigate the means by which… Expand
Methotrexate and its mechanisms of action in inflammatory arthritis
Low-Dose Methotrexate: A Mainstay in the Treatment of Rheumatoid Arthritis
Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis.
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