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Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides.
TLDR
Results not only show that ecto-5'-nucleotidase activity is a critical mediator of methotrexate- and sulfasalazine-induced antiinflammatory activity in vitro and in vivo but also indicate that adenine nucleotides, released from cells, are the source of extracellular adenosine. Expand
Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are
TLDR
There is strong evidence that adenosine mediates the antiinflammatory effects of MTX in this model of RA, and the findings suggest that abstinence from caffeine, a ubiquitous food additive and medication, may enhance the therapeutic effects ofMTX in RA. Expand
Adenosine A2A receptors play a role in the pathogenesis of hepatic cirrhosis
TLDR
It is demonstrated that hepatic adenosine A2A receptors play an active role in the pathogenesis of hepatic fibrosis, and a novel therapeutic target is suggested in the treatment and prevention of Hepatic cirrhosis. Expand
Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68.
TLDR
Findings confirm that adenosine, acting at A(2A) and A(3) receptors, is a potent regulator of inflammation. Expand
Inflammatory Cytokines Regulate Function and Expression of Adenosine A2A Receptors in Human Monocytic THP-1 Cells1
TLDR
Observations suggest that local changes in the cytokine milieu may influence the therapeutic response to those drugs by altering the expression and function of adenosine receptors on inflammatory cells. Expand
Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of
TLDR
The antiinflammatory effects of aspirin and sodium salicylate, but not glucocorticoids, are largely mediated by the antiinflammatory autacoid adenosine independently of inhibition of prostaglandin synthesis by COX-1 or COX2 or of the presence of p105. Expand
Th1 Cytokines Regulate Adenosine Receptors and Their Downstream Signaling Elements in Human Microvascular Endothelial Cells 1
TLDR
The effects of IL-1, TNF-α, and IFN-γ on expression and function of adenosine receptors and select members of their coupling G proteins in human dermal microvascular endothelial cells (HMVEC) are studied to suggest that the interaction between proinflammatory cytokines and adenosines receptors may affect therapeutic responses to anti-inflammatory drugs that act via adenosin-dependent mechanisms. Expand
Wound Healing Is Accelerated by Agonists of Adenosine A2 (Gα s-linked) Receptors
TLDR
It is reported that ligation of the Gαs-linked adenosine receptors on the cells of an artificial wound dramatically alters the kinetics of wound closure and appears to constitute the first evidence that a small molecule, such as anadenosine receptor agonist, accelerates wound healing in both normal animals and in animals with impaired wound healing. Expand
Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma.
TLDR
It is demonstrated that adenosine A2A receptors play an active role in the pathogenesis of dermal fibrosis and suggest a novel therapeutic target in the treatment and prevention of der mal fibrosis in diseases such as scleroderma. Expand
Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A(2A) receptors.
TLDR
Targeting the adenosine A(2A) receptor is a novel approach to promoting wound healing and angiogenesis in normal individuals and those suffering from chronic wounds. Expand
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