• Publications
  • Influence
Adenosine receptors: therapeutic aspects for inflammatory and immune diseases
This work has generated excitement regarding the potential use of adenosine-receptor-based therapies in the treatment of infection, autoimmunity, ischaemia and degenerative diseases. Expand
Adenosine: an endogenous regulator of innate immunity.
Adenosine, a purine nucleoside that is elaborated at injured and inflamed sites, has a central role in the regulation of inflammatory responses and in limiting inflammatory tissue destruction. Expand
Adenosine, an endogenous anti-inflammatory agent.
  • B. Cronstein
  • Biology, Medicine
  • Journal of applied physiology
  • 1994
The observations reviewed here suggest that adenosine and agents that act throughadenosine are excellent candidates for development as anti-inflammatory agents. Expand
Low-Dose Methotrexate: A Mainstay in the Treatment of Rheumatoid Arthritis
The mechanism of action of methotrexate, originally developed as a folate antagonist for the treatment of cancer, and its role in the therapy of rheumatoid arthritis are reviewed. Expand
The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.
Results indicate that methotrexate is a nonsteroidal antiinflammatory agent, the antiphlogistic action of which is due to increased adenosine release at inflamed sites. Expand
The adenosine/neutrophil paradox resolved: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively.
Evidence is reported that two distinct adenosine receptors are found on neutrophils (presumably the A1 and A2 receptors of other cell types) that modulate chemotaxis and O2- generation. Expand
Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides.
Results not only show that ecto-5'-nucleotidase activity is a critical mediator of methotrexate- and sulfasalazine-induced antiinflammatory activity in vitro and in vivo but also indicate that adenine nucleotides, released from cells, are the source of extracellular adenosine. Expand
Adenosine A2A receptors play a role in the pathogenesis of hepatic cirrhosis
It is demonstrated that hepatic adenosine A2A receptors play an active role in the pathogenesis of hepatic fibrosis, and a novel therapeutic target is suggested in the treatment and prevention of Hepatic cirrhosis. Expand
Interleukin-6--a key mediator of systemic and local symptoms in rheumatoid arthritis.
  • B. Cronstein
  • Medicine
  • Bulletin of the NYU hospital for joint diseases
  • 2007
Animal studies support the concept that this cytokine plays a role in the development of inflammatory arthritis, and clinical trials with tocilizumab, a humanized monoclonal antibody to soluble IL-6R, have shown that blocking IL- 6 signaling reduces RA symptoms and markers of disease activity. Expand
Molecular action of methotrexate in inflammatory diseases
In confirmation of this mechanism of action, recent studies in both animals and patients suggest that adenosine-receptor antagonists, among which is caffeine, reverse or prevent the anti-inflammatory effects of methotrexate. Expand