• Publications
  • Influence
Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice.
Most, but not all, CNS effects of Delta9-THC are mediated by the CB1 receptor, which accounts for the abuse potential of cannabis, while other effects such as analgesia suggest potential medicinal applications.
Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.
It is suggested that Abn-cbd and cannabidiol are a selective agonist and antagonist, respectively, of an as-yet-unidentified endothelial receptor for anandamide, activation of which elicits NO-independent mesenteric vasodilation, possibly by means of the release of an endothelium-derived hyperpolarizing factor (EDHF).
Peripheral cannabinoid receptor, CB2, regulates bone mass.
  • O. Ofek, M. Karsak, +10 authors I. Bab
  • Medicine
    Proceedings of the National Academy of Sciences…
  • 17 January 2006
It is shown that CB2-deficient mice have a markedly accelerated age-related trabecular bone loss and cortical expansion, although cortical thickness remains unaltered, demonstrating that the endocannabinoid system is essential for the maintenance of normal bone mass by osteoblastic and osteoclastic CB2 signaling.
GlyR α3: An Essential Target for Spinal PGE2-Mediated Inflammatory Pain Sensitization
It is demonstrated that inhibition of a specific glycine receptor subtype (GlyR α3) by PGE2-induced receptor phosphorylation underlies central inflammatory pain sensitization and may provide a previously unrecognized molecular target in pain therapy.
A Humanized Version of Foxp2 Affects Cortico-Basal Ganglia Circuits in Mice
In the striatum, a part of the basal ganglia affected in humans with a speech deficit due to a nonfunctional FOXP2 allele, it is found that medium spiny neurons have increased dendrite lengths and increased synaptic plasticity, suggesting that alterations in cortico-basal ganglia circuits might have been important for the evolution of speech and language in humans.
Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor.
The results suggest that cannabinoid CB(2) receptor-specific ligands may be clinically useful in the modulation of macrophage immune function while exhibiting no central nervous system activity.
The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development.
The partially overlapping expression pattern with that of cellular retinoid binding proteins suggests that B-FABP is involved in the metabolism of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development.
Presynaptic Cannabinoid Sensitivity Is a Major Determinant of Depolarization-Induced Retrograde Suppression at Hippocampal Synapses
Results indicate that presynaptic cannabinoid sensitivity is a major factor that determines the extent of DSI and DSE, and that both DSE and DSI were mediated by the cannabinoid CB1 receptor.
Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome
It is shown that ptc heterozygous mice exhibit increased incidence of radiation-induced teratogenesis, which suggests a role for ptc in the response to ionizing radiation and provides a model for both the systemic and stochastic abnormalities observed in Gorlin syndrome.
Beta-caryophyllene is a dietary cannabinoid
Peroral (E)-BCP at 5 mg/kg strongly reduces the carrageenan-induced inflammatory response in wild-type mice but not in mice lacking CB2 receptors, providing evidence that this natural product exerts cannabimimetic effects in vivo.