Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice.
- A. Zimmer, A. Zimmer, A. Hohmann, M. Herkenham, T. Bonner
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 11 May 1999
Most, but not all, CNS effects of Delta9-THC are mediated by the CB1 receptor, which accounts for the abuse potential of cannabis, while other effects such as analgesia suggest potential medicinal applications.
Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.
- Z. Járai, J. Wagner, G. Kunos
- Biology, MedicineProceedings of the National Academy of Sciences…
- 23 November 1999
It is suggested that Abn-cbd and cannabidiol are a selective agonist and antagonist, respectively, of an as-yet-unidentified endothelial receptor for anandamide, activation of which elicits NO-independent mesenteric vasodilation, possibly by means of the release of an endothelium-derived hyperpolarizing factor (EDHF).
Beta-caryophyllene is a dietary cannabinoid
- J. Gertsch, M. Leonti, A. Zimmer
- BiologyProceedings of the National Academy of Sciences
- 1 July 2008
Peroral (E)-BCP at 5 mg/kg strongly reduces the carrageenan-induced inflammatory response in wild-type mice but not in mice lacking CB2 receptors, providing evidence that this natural product exerts cannabimimetic effects in vivo.
Peripheral cannabinoid receptor, CB2, regulates bone mass.
- O. Ofek, M. Karsak, I. Bab
- Biology, MedicineProceedings of the National Academy of Sciences…
- 17 January 2006
It is shown that CB2-deficient mice have a markedly accelerated age-related trabecular bone loss and cortical expansion, although cortical thickness remains unaltered, demonstrating that the endocannabinoid system is essential for the maintenance of normal bone mass by osteoblastic and osteoclastic CB2 signaling.
GlyR α3: An Essential Target for Spinal PGE2-Mediated Inflammatory Pain Sensitization
- R. Harvey, Ulrike B Depner, U. Müller
- BiologyScience
- 7 May 2004
It is demonstrated that inhibition of a specific glycine receptor subtype (GlyR α3) by PGE2-induced receptor phosphorylation underlies central inflammatory pain sensitization and may provide a previously unrecognized molecular target in pain therapy.
The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development.
- A. Kurtz, A. Zimmer, F. Schnütgen, G. Brüning, F. Spener, T. Müller
- Biology, ChemistryDevelopment
- 1 September 1994
The partially overlapping expression pattern with that of cellular retinoid binding proteins suggests that B-FABP is involved in the metabolism of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development.
Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome
- H. Hahn, L. Wojnowski, A. Zimmer, Jennifer Hall, G. Miller, A. Zimmer
- Medicine, BiologyNature Network Boston
- 1 May 1998
It is shown that ptc heterozygous mice exhibit increased incidence of radiation-induced teratogenesis, which suggests a role for ptc in the response to ionizing radiation and provides a model for both the systemic and stochastic abnormalities observed in Gorlin syndrome.
Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor.
- N. E. Buckley, K. McCoy, M. Glass
- Biology, ChemistryEuropean Journal of Pharmacology
- 19 May 2000
Presynaptic Cannabinoid Sensitivity Is a Major Determinant of Depolarization-Induced Retrograde Suppression at Hippocampal Synapses
- T. Ohno‐Shosaku, H. Tsubokawa, I. Mizushima, Norihide Yoneda, A. Zimmer, M. Kano
- BiologyJournal of Neuroscience
- 15 May 2002
Results indicate that presynaptic cannabinoid sensitivity is a major factor that determines the extent of DSI and DSE, and that both DSE and DSI were mediated by the cannabinoid CB1 receptor.
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