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Protein Patched Homolog 1, human

Known as: Protein Patched Homolog 1, Patched, PTCH 
Protein patched homolog 1 (1447 aa, ~161 kDa) is encoded by the human PTCH1 gene. This protein is involved in the modulation of hedgehog protein… 
National Institutes of Health

Related topics

Related topics

17 relations
Axon GuidanceBiologic DevelopmentCellular MembraneEmbryonic Development

Broader (1)

Patched Receptors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Evidence for Antibody-Mediated Injury as a Major Determinant of Late Kidney Allograft Failure
Background. Late graft failure (LGF) is believed to be the consequence of immunologic and nonimmunologic insults leading to… 
Review
2003
Review
2003
UV-induced skin damage.
Review
2000
Review
2000
The molecular basis of lung morphogenesis
Highly Cited
2000
Highly Cited
2000
Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened
Highly Cited
1997
Highly Cited
1997
Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours
Sporadic basal cell carcinoma (BCC) is the most common type of malignant cancer in fair-skinned adults. Familial BCCs and a… 
Highly Cited
1997
Highly Cited
1997
Basal cell carcinomas in mice overexpressing sonic hedgehog.
Mutations in the tumor suppressor gene PATCHED (PTC) are found in human patients with the basal cell nevus syndrome, a disease… 
Highly Cited
1997
Highly Cited
1997
Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis.
Branching morphogenesis of the embryonic lung requires interactions between the epithelium and the mesenchyme. Previously, we… 
Highly Cited
1996
Highly Cited
1996
Biochemical evidence that Patched is the Hedgehog receptor
THE protein Sonic hedgehog (Shh) is essential for a variety of patterning events during development. It is the signal from the… 
Highly Cited
1996
Highly Cited
1996
Dual Roles for Patched in Sequestering and Transducing Hedgehog
Review
1996
Review
1996
Is human patched the gatekeeper of common skin cancers?
Basal cell carcinoma (BCC) is the most common cancer in humans1. The majority of sporadic BCCs have allelic loss on chromosome… 
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