Dual Roles for Patched in Sequestering and Transducing Hedgehog

@article{Chen1996DualRF,
  title={Dual Roles for Patched in Sequestering and Transducing Hedgehog},
  author={Yu Chen and Gary Struhl},
  journal={Cell},
  year={1996},
  volume={87},
  pages={553-563}
}
Secreted proteins of the Hedgehog (Hh) family have diverse organizing roles in animal development. Recently, a serpentine protein Smoothened (Smo) has been proposed as a Hh receptor. Here, we present evidence that implicates another multiple-pass transmembrane protein, Patched (Ptc), in Hh reception and suggests a novel signal transduction mechanism in which Hh binds to Ptc, or a Ptc-Smo complex, and thereby induces Smo activity. Our results also show that Ptc limits the range of Hh action; we… Expand
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TLDR
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TLDR
A role of the SSD of Ptc in mediating the vesicular trafficking of PTC to regulate Smoothened activity is suggested. Expand
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TLDR
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