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Altered neural cell fates and medulloblastoma in mouse patched mutants.
The PATCHED (PTC) gene encodes a Sonic hedgehog (Shh) receptor and a tumor suppressor protein that is defective in basal cell nevus syndrome (BCNS). Functions of PTC were investigated by inactivatingExpand
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
It is shown that the plant-derived teratogen cyclopamine, which inhibits the Hh response, is a potential ‘mechanism-based’ therapeutic agent for treatment of these tumours. Expand
Patched1 Regulates Hedgehog Signaling at the Primary Cilium
The role of primary cilia in regulation of Patched1 (Ptc1), the receptor for Sonic Hedgehog (Shh), is investigated and it is found that Ptc1 localized to cilia and inhibited Smoothened (Smo) by preventing its accumulation within cilia. Expand
Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.
A mouse homolog of ptc is identified which in many tissues is transcribed near cells making either Sonic or Indian hedgehog, and ectopic Sonic hedgehog expression in the mouse central nervous system induces ptc transcription. Expand
Human Homolog of patched, a Candidate Gene for the Basal Cell Nevus Syndrome
Heritable mutations in BCNS patients and a somatic mutation in a sporadic BCC were identified in a human homolog of the Drosophila patched (ptc) gene, which appears to be crucial for proper embryonic development and for tumor suppression. Expand
Control of Neuronal Precursor Proliferation in the Cerebellum by Sonic Hedgehog
It is shown that Sonic hedgehog (Shh), which is made by Purkinje cells, regulates the division of granule cell precursors (GCPs), and treatment of GCPs with Shh prevents differentiation and induces a potent, long-lasting proliferative response. Expand
Prickle Mediates Feedback Amplification to Generate Asymmetric Planar Cell Polarity Signaling
A Prickle-dependent intercellular feedback loop is described that generates asymmetric Frizzled and Dishevelled localization and functions in a feedback loop that amplifies differences betweenFrizzled levels on adjacent cell surfaces. Expand
Progressive ataxia, myoclonic epilepsy and cerebellar apoptosis in cystatin B-deficient mice
Evidence is provided that cystatin B, a non-caspase cysteine protease inhibitor, has a role in preventing cerebellar apoptosis in EPM1 mice. Expand
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
It is shown that Re can form a physical complex with a newly cloned vertebrate homologue of the Drosophila protein Smoothened (vSmo), and that vSmo is coexpressed with vPtc in many tissues but does not bind Shh directly. Expand
Communicating with Hedgehogs
  • J. Hooper, M. Scott
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • 1 April 2005
Signalling by secreted Hedgehog (Hh) proteins is important for the development of many tissues and organs and the cellular machinery that is responsible for the unique molecular mechanisms of Hh signal transduction has been largely conserved during metazoan evolution. Expand