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Protein Jagged-1, human

Known as: Jagged protein, human, jagged 1 (Alagille syndrome) protein, human, jagged 1 protein, human 
Protein jagged-1 (1218 aa, ~134 kDa) is encoded by the human JAG1 gene. This protein may be involved in the development of the hematopoietic system.
National Institutes of Health

Related topics

Related topics

14 relations
Cell Differentiation processCell Fate ControlEGF-Like DomainIntegral Membrane Proteins

Broader (1)

Jagged-1 Protein

Papers overview

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Highly Cited
2009
Highly Cited
2009
Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer
Notch has been linked to β-catenin-dependent tumorigenesis; however, the mechanisms leading to Notch activation and the… 
Review
2008
Review
2008
The molecular logic of Notch signaling – a structural and biochemical perspective
The Notch signaling pathway constitutes an ancient and conserved mechanism for cell-cell communication in metazoan organisms, and… 
Highly Cited
2006
Highly Cited
2006
Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear
Each of the sensory patches in the epithelium of the inner ear is a mosaic of hair cells and supporting cells. Notch signalling… 
Highly Cited
2004
Highly Cited
2004
Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1.
Fringe O-fucose-beta1,3-N-acetylglucosaminyltransferases modulate Notch signaling by potentiating signaling induced by Delta-like… 
Highly Cited
2002
Highly Cited
2002
Multiple sclerosis: Re-expression of a developmental pathway that restricts oligodendrocyte maturation
During mammalian central nervous system (CNS) development, contact-mediated activation of Notch1 receptors on oligodendrocyte… 
Highly Cited
2002
Highly Cited
2002
Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma.
Notch signaling controls cell fate decisions of hematopoietic progenitors by inhibiting certain steps of differentiation and… 
Highly Cited
2001
Highly Cited
2001
Activated Notch2 Signaling Inhibits Differentiation of Cerebellar Granule Neuron Precursors by Maintaining Proliferation
Highly Cited
2001
Highly Cited
2001
The Notch ligand Jagged1 is required for inner ear sensory development
Within the mammalian inner ear there are six separate sensory regions that subserve the functions of hearing and balance… 
Highly Cited
1999
Highly Cited
1999
Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1.
The Notch signaling pathway is an evolutionarily conserved intercellular signaling mechanism essential for embryonic development… 
Highly Cited
1999
Highly Cited
1999
Mouse Jagged1 Physically Interacts with Notch2 and Other Notch Receptors
The Delta/Serrate/LAG-2 (DSL) domain containing proteins are considered to be ligands for Notch receptors. However, the physical… 
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