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Protein Jagged-1, human

Known as: Jagged protein, human, jagged 1 (Alagille syndrome) protein, human, jagged 1 protein, human 
Protein jagged-1 (1218 aa, ~134 kDa) is encoded by the human JAG1 gene. This protein may be involved in the development of the hematopoietic system.
National Institutes of Health

Related topics

Related topics

14 relations
Cell Differentiation processCell Fate ControlEGF-Like DomainIntegral Membrane Proteins

Broader (1)

Jagged-1 Protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Notch Ligand DLL4 Alleviates Allergic Airway Inflammation via Induction of a Homeostatic Regulatory Pathway
Notch is a pleiotropic signaling family that has been implicated in pathogenesis of allergic airway diseases; however, the… 
2013
2013
The role of Notch and gamma-secretase inhibition in an ovarian cancer model.
BACKGROUND The Notch pathway is dysregulated in ovarian cancer. We sought to examine the role of Notch and gamma-secretase (GS… 
2011
2011
Epidermal Growth Factor–Like Domain 7 Is a Novel Inhibitor of Neutrophil Adhesion to Coronary Artery Endothelial Cells Injured by Calcineurin Inhibition
Background— We investigated the effect of epidermal growth factor–like domain 7 (Egfl7) on nuclear factor-&kgr;B activation… 
2009
2009
Notch activation induces neurite remodeling and functional modifications in SH‐SY5Y neuronal cells
Notch proteins are definitely recognized as key regulators of the neuronal fate during embryo development, but their function in… 
2008
2008
Notch 1 Signaling and Regulatory T Cell Function
2008
2008
Clonal Analysis of Hematopoiesis-Supporting Activity of Human Mesenchymal Stem Cells in Association with Jagged1 Expression and Osteogenic Potential
Human mesenchymal stem cells (hMSCs) are promising feeder cells for expanding hematopoietic stem cells (HSCs), but their… 
2006
2006
Notch3 intracellular domain accumulates in HepG2 cell line.
BACKGROUND By mediating local cell-cell interactions, the Notch signaling pathway seems to control a variety of processes from… 
Highly Cited
2002
Highly Cited
2002
Activated Notch 1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma
Notch signaling controls cell fate decisions of hematopoietic progenitors by inhibiting certain steps of differentiation and… 
2000
2000
CADASIL: Notch signaling defect or protein accumulation problem?
When studies of the genetic etiology of human disease intersect with those of basic mechanisms in developmental biology, our… 
1999
1999
Expression pattern of Notch 1 , 2 and 3 and Jagged 1 and 2 in lymphoid and stromal thymus components : distinct ligand – receptor interactions in intrathymic T cell development
The suggested role of Notch1 or its mutants in thymocyte differentiation and T cell tumorigenesis raises the question of how the… 
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