Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1.

@article{Xue1999EmbryonicLA,
  title={Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1.},
  author={Yali Xue and Xia Gao and Claire E. Lindsell and Christine R. Norton and B. -Y. Chang and Carol Hicks and Maureen Gendron-Maguire and Elizabeth B. Rand and Gerry Weinmaster and Thomas Gridley},
  journal={Human molecular genetics},
  year={1999},
  volume={8 5},
  pages={723-30}
}
The Notch signaling pathway is an evolutionarily conserved intercellular signaling mechanism essential for embryonic development in mammals. Mutations in the human JAGGED1 ( JAG1 ) gene, which encodes a ligand for the Notch family of transmembrane receptors, cause the autosomal dominant disorder Alagille syndrome. We have examined the in vivo role of the mouse Jag1 gene by creating a null allele through gene targeting. Mice homozygous for the Jag1 mutation die from hemorrhage early during… CONTINUE READING
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