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The 2016 revision of the World Health Organization classification of lymphoid neoplasms.
The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies. Expand
A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group.
An international review of lymphomas found that each of us had independently evolved ways of viewing these diseases that were essentially identical, and there was little divergence between European and US participants. Expand
Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67.
- J. Gerdes, H. Lemke, H. Baisch, H. Wacker, U. Schwab, H. Stein
- Biology, Medicine
- Journal of immunology
- 1 October 1984
The data suggest that the early stages of mitogen stimulation represent initial sequences of proliferation and not parts of the cell cycle, and immunostaining with monoclonal antibody Ki-67 provides a reliable means of rapidly evaluating the growth fraction of normal and neoplastic human cell populations. Expand
The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications.
The criteria and significance of early or precursor lesions and the identification of certain lymphoid neoplasms largely associated with particular age groups, such as children and the elderly are addressed, and the issue of borderline categories having overlapping features with large B-cell lymphomas is reviewed. Expand
A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling.
- M. Hummel, S. Bentink, +32 authors R. Siebert
- Biology, Medicine
- The New England journal of medicine
- 8 June 2006
The molecular definition of Burkitt's lymphoma clarifies and extends the spectrum of the WHO criteria for Burkitt’s lymphoma. Expand
Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection.
A series of 16 highly malignant diffuse large B-cell lymphomas of the oral cavity with unique immunohistologic features that developed in human immunodeficiency virus-positive patients are reported, and it is proposed to name these tumors plasmablastic lymphomas, in accordance with their morphologic and immunohISTologic features. Expand
The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated…
Results obtained indicate that Ki-1 antigen is an inducible lymphoid-associated molecule that identifies a group of hitherto poorly characterized normal and neoplastic large lymphoid cells in Hodgkin's disease and Disorders in which only a minority of cells express Ki- 1 antigen probably represent lesions in whichonly some of the abnormal cells have transformed into an "activation state. Expand
A revised European-American classification of lymphoid neoplasms : a proposal from the international lymphoma study group
Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation
- J. Gerdes, U. Schwab, H. Lemke, H. Stein
- Biology, Medicine
- International journal of cancer
- 15 January 1983
A first series of immunostainings of tumour biopsies indicated that Ki‐67 may be a potent tool for easy and quick evaluation of the proportion of proliferating cells in a tumour. Expand
CD30(+) anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features.
Recent immunohistologic studies suggest that ALCLs Hodgkin-like represent either cases of tumor cell-rich classic Hodgkin disease or (less commonly) ALK(+) ALCL orALK(-) ALCL, both of which have an unfavorable prognosis. Expand