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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TLDR
It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM). Expand
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TLDR
It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM). Expand
CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs
TLDR
Analysis of gene-targeted mice identified the chemokine receptor CCR7 as an important organizer of the primary immune response, and found that lymphocytes and dendritic cells fail to migrate into the draining lymph nodes upon activation, resulting in impaired migration of lymphocytes. Expand
CCR7 and its ligands: balancing immunity and tolerance
TLDR
This work focuses on the cellular and molecular mechanisms that enable CCR7 and its two ligands, CCL19 and CCL21, to balance immunity and tolerance. Expand
A chemokine-driven positive feedback loop organizes lymphoid follicles
TLDR
It is established that B-lymphocyte chemoattractant (BLC/BCA1) and its receptor, CXCR5, are needed for B-cell homing to follicles in lymph nodes as well as in spleen, and that BLC is required for the development of most lymph nodes and Peyer's patches. Expand
Rapid leukocyte migration by integrin-independent flowing and squeezing
TLDR
It is shown here that functional integrins do not contribute to migration in three-dimensional environments, and these cells migrate by the sole force of actin-network expansion, which promotes protrusive flowing of the leading edge. Expand
Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production
Chemokines and their receptors have been identified as major regulators controlling the functional organization of secondary lymphoid organs. Here we show that expression of CXC chemokine receptor 5Expand
CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
CD40 ligand (CD40L, CD154), a transmembrane protein structurally related to the cytokine TNF-α, was originally identified on stimulated CD4+ T cells, and later on stimulated mast cells and basophils.Expand
CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions.
TLDR
The data identify CCR7 as a key regulator that governs trafficking of skin DC under both inflammatory and steady-state conditions and provides evidence that these cells represent a semimature population of DC that is capable of initiating T cell proliferation under conditions known to induce tolerance. Expand
Skewed maturation of memory HIV-specific CD8 T lymphocytes
TLDR
A skewed maturation of HIV-specific memory CD8+ T cells during HIV infection is demonstrated through analysis of cell division, which demonstrates a two-step process characterized initially by a phase of proliferation largely restricted to the CCR7+CD8+ cell subsets, followed by aphase of functional maturation encompassing the C CR7-CD8- cell subset. Expand
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