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Properdin

Known as: Complement factor P, Factor P, Complement, factor P 
A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It… 
National Institutes of Health

Related topics

Related topics

15 relations
CFP geneComplement Pathway, AlternativeProcess of secretionagonists

Broader (2)

Gamma globulinImmunologic Factors

Narrower (3)

Human ProperdinPROPERDIN DEFICIENCY, X-LINKEDproperdistatin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1995
Highly Cited
1995
Characterization of mutant forms of recombinant human properdin lacking single thrombospondin type I repeats. Identification of modules important for function.
Properdin is a serum glycoprotein that up-regulates the alternative pathway of complement by stabilizing the C3b-Bb complex. It… 
1993
1993
New procedure for the detection of complement deficiency by ELISA. Analysis of activation pathways and circumvention of rheumatoid factor influence.
Highly Cited
1989
Highly Cited
1989
Antistasin, an inhibitor of coagulation and metastasis, binds to sulfatide (Gal(3-SO4) beta 1-1Cer) and has a sequence homology with other proteins that bind sulfated glycoconjugates.
1988
1988
A second variant of properdin deficiency: the detection of properdin at low concentrations in affected males.
A selective deficiency of properdin (P) was identified in a 58-year-old male and in his 29-year-old nephew, both of whom were… 
1988
1988
A 34-amino acid peptide of the third component of complement mediates properdin binding.
In this study, a peptide of 34 amino acids from the Mr 40,000 C terminus alpha-chain fragment of C3 was found to mediate… 
Highly Cited
1980
Highly Cited
1980
Raji cell injury and subsequent lysis by the purified cytolytic alternative pathway of human complement.
Highly Cited
1975
Highly Cited
1975
Selective deficiency of the second component of complement in a patient with anaphylactoid purpura.
1975
1975
Dermal‐epidermal deposition of complement components and properdin in systemic lupus erythematosus
Skin lesions and clinically normal skin of thirteen patients with systemic lupus erythematosus (SLE) were examined, by the use of… 
1974
1974
PROPERDIN FACTOR D
The protein in the properdin pathway responsible for conversion of precursor factor D to D has been isolated and found to be… 
1974
1974
The role of immunoglobulin in the interaction of pneumococci and the properdin pathway: evidence for its specificity and lack of requirement for the Fc portion of the molecule.
In previous studies on the interaction of pneumococci and the heat labile opsonin (HLO) system it was found that C3 was fixed… 
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