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Properdin

Known as: Complement factor P, Factor P, Complement, factor P 
A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
The alternative pathway (AP) of complement activation is constitutively active and must be regulated by host proteins to prevent… Expand
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Highly Cited
2008
Highly Cited
2008
Apoptotic cells must be rapidly eliminated to avoid harmful inflammatory and autoimmune reactions. Innate immunity is designed… Expand
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Highly Cited
2008
Highly Cited
2008
Cells that undergo apoptosis or necrosis are promptly removed by phagocytes. Soluble opsonins such as complement can opsonize… Expand
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Highly Cited
2007
Highly Cited
2007
Complement promotes the rapid recognition and elimination of pathogens, infected cells, and immune complexes. The biochemical… Expand
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Highly Cited
2006
Highly Cited
2006
Complement is a powerful host defense system that contributes to both innate and acquired immunity. There are three pathways of… Expand
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Highly Cited
1999
Highly Cited
1999
BACKGROUND The reasons why meningococcal disease develops in only a small proportion of individuals carrying the causative… Expand
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Highly Cited
1997
Highly Cited
1997
Properdin is an important regulatory constituent of the complement system. In contrast to most other components of complement… Expand
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Highly Cited
1977
Highly Cited
1977
Bacterial lipopolysaccharides (LPS) have been demonstrated to activate both the classical and the properdin pathways of… Expand
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Highly Cited
1976
Highly Cited
1976
An inhibitory activity for an erythrocyte in termediate bearing the properdin (P)-stabilized amplification C3 convertase, PC3bBb… Expand
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Highly Cited
1975
Highly Cited
1975
A function of P in the alternative complement pathway is to prolong the first order decay of the hemolytic sites on EAC43B in a… Expand
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