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Properdin

Known as: Complement factor P, Factor P, Complement, factor P 
A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It… 
National Institutes of Health

Related topics

Related topics

15 relations
CFP geneComplement Pathway, AlternativeProcess of secretionagonists

Broader (2)

Gamma globulinImmunologic Factors

Narrower (3)

Human ProperdinPROPERDIN DEFICIENCY, X-LINKEDproperdistatin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1995
Highly Cited
1995
Characterization of mutant forms of recombinant human properdin lacking single thrombospondin type I repeats. Identification of modules important for function.
Properdin is a serum glycoprotein that up-regulates the alternative pathway of complement by stabilizing the C3b-Bb complex. It… 
Highly Cited
1993
Highly Cited
1993
Properdin, a positive regulator of complement activation, is expressed in human T cell lines and peripheral blood T cells.
Properdin plays an important regulatory role in the activation of the complement system. Here we report the biosynthesis of… 
Highly Cited
1989
Highly Cited
1989
Antistasin, an inhibitor of coagulation and metastasis, binds to sulfatide (Gal(3-SO4) beta 1-1Cer) and has a sequence homology with other proteins that bind sulfated glycoconjugates.
Highly Cited
1988
Highly Cited
1988
Properdin, the terminal complement components, thrombospondin and the circumsporozoite protein of malaria parasites contain similar sequence motifs
Properdin is a plasma glycoprotein which stabilizes the C3bnBb¯ enzyme complex of the alternative pathway of the complement… 
1988
1988
A second variant of properdin deficiency: the detection of properdin at low concentrations in affected males.
A selective deficiency of properdin (P) was identified in a 58-year-old male and in his 29-year-old nephew, both of whom were… 
Highly Cited
1980
Highly Cited
1980
Raji cell injury and subsequent lysis by the purified cytolytic alternative pathway of human complement.
Highly Cited
1976
Highly Cited
1976
Activation of the alternative complement pathway by lymphoblastoid cell lines derived from patients with Burkitt's lymphoma and infectious mononucleosis.
Highly Cited
1975
Highly Cited
1975
Selective deficiency of the second component of complement in a patient with anaphylactoid purpura.
1974
1974
PROPERDIN FACTOR D
The protein in the properdin pathway responsible for conversion of precursor factor D to D has been isolated and found to be… 
1974
1974
The role of immunoglobulin in the interaction of pneumococci and the properdin pathway: evidence for its specificity and lack of requirement for the Fc portion of the molecule.
In previous studies on the interaction of pneumococci and the heat labile opsonin (HLO) system it was found that C3 was fixed… 
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