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Cutting Edge: Human CD4+CD25+ T Cells Restrain the Maturation and Antigen-Presenting Function of Dendritic Cells1
It is shown that regulatory T cells render the DC inefficient as APCs despite prestimulation with CD40 ligand, and this effect was marginally reverted by neutralizing Abs to TGF-β and reduced expression of costimulatory molecules in DC. Expand
Expansion of CD4+CD25+ regulatory T cells by intravenous immunoglobulin: a critical factor in controlling experimental autoimmune encephalomyelitis.
It is shown that prophylactic infusion of IVIg prevents the development of experimental autoimmune encephalomyelitis (EAE), an accepted animal model for multiple sclerosis (MS), and the protection was Treg-mediated because IVIG failed to protect against EAE in mice that were depleted of the Treg population. Expand
High Prevalence of Anal Human Papillomavirus Infection and Anal Cancer Precursors among HIV-Infected Persons in the Absence of Anal Intercourse
The role of HIV-related immunodeficiency in detecting anal HPV infection and anal disease in the absence of anal intercourse was assessed and costbenefit modeling over a wide range of assumptions suggested anal cytologic screening in HIV-positive men who have sex with men has been projected to be cost-effective for preventing anal cancer. Expand
Clinical Outcome of Patients with HIV-1 Infection according to Immunologic and Virologic Response after 6 Months of Highly Active Antiretroviral Therapy
Clinical outcomes are reported in a large cohort of patients in France 24 months after initiation of triple therapy that contained protease inhibitors, according to virologic and immunologic response at 6 months, and the long-term prognosis of patients exhibiting such discordant responses remains unknown. Expand
Mapping of the Region of Complement Receptor (CR) 1 Required for Plasmodium falciparum Rosetting and Demonstration of the Importance of CR1 in Rosetting in Field Isolates1
The region of CR1 required for rosetting is mapped and it is demonstrated that the CR1-dependent rosetting mechanism occurs commonly in P. falciparum isolates, and could therefore be a potential target for future therapeutic interventions to treat severe malaria. Expand
High Prevalence of Anal Squamous Intraepithelial Lesions in HIV-Positive Men Despite the Use of Highly Active Antiretroviral Therapy
A high prevalence of anal SIL, including high-grade SIL, and anal HPV infection in HIV-infected MSM despite immune restoration under HAART is demonstrated. Expand
Early regression of cervical lesions in HIV‐seropositive women receiving highly active antiretroviral therapy
It is demonstrated that active antiretroviral therapy may result in a reduced prevalence of cervical squamous intra-epithelial lesions despite the absence of clearance of HPV infection. Expand
Human alternative complement pathway: membrane-associated sialic acid regulates the competition between B and beta1 H for cell-bound C3b.
The relative affinity of B and β1H for particle-bound C3b is influenced by the relative abundance of cell surface sialic acid moieties and determines whether or not the particle has the capacity toExpand
Self-reactive antibodies (natural autoantibodies) in healthy individuals.
The current knowledge on the physicochemical and functional properties of NAA in man, and the use of N AA for therapeutic intervention is focused on. Expand