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Human Properdin

Known as: Complement Factor P, Factor P, Properdin 
Properdin (469 aa, ~51 kDa) is encoded by the human CFP gene. This protein plays a role in the stabilization of complement convertases of the… Expand
National Institutes of Health

Related topics

Related topics

8 relations
CFP geneCFP wt AlleleComplement ActivationComplement Pathway, Alternative
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Broader (1)

Properdin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Properdin binding to complement activating surfaces depends on initial C3b deposition
Significance The role of properdin in stabilization of the alternative pathway C3 convertase is indisputable, whereas its role as… Expand
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Highly Cited
2013
Highly Cited
2013
Identification of a Novel Mode of Complement Activation on Stimulated Platelets Mediated by Properdin and C3(H2O)
Elevated numbers of activated platelets circulate in patients with chronic inflammatory diseases, including atherosclerosis and… Expand
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Highly Cited
2010
Highly Cited
2010
Native polymeric forms of properdin selectively bind to targets and promote activation of the alternative pathway of complement.
Properdin, a positive regulator of the complement system, has recently been reported to bind to certain pathogenic microorganisms… Expand
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Highly Cited
2010
Highly Cited
2010
An Evaluation of the Role of Properdin in Alternative Pathway Activation on Neisseria meningitidis and Neisseria gonorrhoeae
Properdin, a positive regulator of the alternative pathway (AP) of complement is important in innate immune defenses against… Expand
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Highly Cited
2008
Highly Cited
2008
Activator-specific requirement of properdin in the initiation and amplification of the alternative pathway complement.
Properdin is a positive regulator of alternative pathway (AP) complement. The current understanding of properdin function is that… Expand
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Highly Cited
2000
Highly Cited
2000
Properdin, the Positive Regulator of Complement, Is HighlyC-Mannosylated*
Properdin is the positive regulator of the alternative pathway of complement activation. The 53-kDa protein is essentially… Expand
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Highly Cited
1989
Highly Cited
1989
Analysis of the natural polymeric forms of human properdin and their functions in complement activation.
Many of the anomalies observed in studies or properdin may be explained on the basis of its ability to form a series of multi… Expand
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Highly Cited
1984
Highly Cited
1984
Molecular architecture of human properdin, a positive regulator of the alternative pathway of complement.
The structure of the human properdin molecule was investigated by hydrodynamic, spectroscopic, and transmission electron… Expand
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Highly Cited
1979
Highly Cited
1979
Serum Complement Levels in Infancy: Age Related Changes
Summary: Levels of eight complement components and two control proteins, were determined on cord serum from normal full term… Expand
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1956
1956
THE PROPERDIN SYSTEM AND IMMUNITY
Methods for the preparation and standardization of reagents suitable for studies on the bactericidal action of the properdin… Expand
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