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Human Properdin

Known as: Complement Factor P, Factor P, Properdin 
Properdin (469 aa, ~51 kDa) is encoded by the human CFP gene. This protein plays a role in the stabilization of complement convertases of the… 
National Institutes of Health

Related topics

Related topics

8 relations
CFP geneCFP wt AlleleComplement ActivationComplement Pathway, Alternative

Broader (1)

Properdin

Papers overview

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Highly Cited
2010
Highly Cited
2010
An Evaluation of the Role of Properdin in Alternative Pathway Activation on Neisseria meningitidis and Neisseria gonorrhoeae
Properdin, a positive regulator of the alternative pathway (AP) of complement is important in innate immune defenses against… 
2000
2000
Interaction of C3b(2)--IgG complexes with complement proteins properdin, factor B and factor H: implications for amplification.
Nascent C3b can form ester bonds with various target molecules on the cell surface and in the fluid phase. Previously, we showed… 
Highly Cited
1991
Highly Cited
1991
Molecular cloning of the cDNA coding for properdin, a positive regulator of the alternative pathway of human complement
Northern blot analysis indicated that the mRNA for human properdin is approximately 1.5 kb long and that its level in U‐937 cells… 
1989
1989
Secondary structure in properdin of the complement cascade and related proteins: a study by Fourier transform infrared spectroscopy.
Six structural repeat motifs of 58 amino acids are found in the sequence of both mouse and human properdins. Twelve more examples… 
1987
1987
Bactericidal activity for Neisseria meningitidis in properdin-deficient sera.
We investigated serum bactericidal reactions against Neisseria meningitidis (serogroups A, B, C, D, Y, W-135, 29E, X, and Z) in… 
1981
1981
Solubilization of immune precipitates by six isolated alternative pathway proteins
Immune precipitates were solubilized by the alternative pathway of complement assembled from isolated proteins, i.e., C3, factor… 
1980
1980
Native and activated properdin: interconvertibility and identity of amino- and carboxy-terminal sequences.
The development of a two-step purification procedure of native properdin with good yield has allowed the physical and chemical… 
Review
1977
Review
1977
The heterocytotoxicity of human serum. I. Activation of the alternative complement pathway by heterologous target cells.
1973
1973
Solid phase radioimmunoassay of properdin.
Highly Cited
1956
Highly Cited
1956
ELEVATION OF PROPERDIN LEVELS IN MICE FOLLOWING ADMINISTRATION OF BACTERIAL LIPOPOLYSACCHARIDES
The administration of a single small dose of bacterial lipopolysaccharide produces in mice a considerable rise in properdin… 
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