Human Properdin

Known as: Complement Factor P, Factor P, Properdin 
Properdin (469 aa, ~51 kDa) is encoded by the human CFP gene. This protein plays a role in the stabilization of complement convertases of the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1953-2018
051019532017

Related topics

Related topics

8 relations
CFP geneCFP wt AlleleComplement ActivationComplement Pathway, Alternative
(More)

Broader (1)

Properdin

Related mentions per year

Related mentions per year

1936-2019
19401960198020002020
Human Properdin
Complement System Proteins
Extracellular Space
CFP gene
Immunity
Complement Activation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Native properdin binds to Chlamydia pneumoniae and promotes complement activation.
Activation of complement represents one means of natural resistance to infection from a wide variety of potential pathogens… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2010
2010
Native polymeric forms of properdin selectively bind to targets and promote activation of the alternative pathway of complement.
Properdin, a positive regulator of the complement system, has recently been reported to bind to certain pathogenic microorganisms… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Activator-specific requirement of properdin in the initiation and amplification of the alternative pathway complement.
Properdin is a positive regulator of alternative pathway (AP) complement. The current understanding of properdin function is that… (More)
Is this relevant?
2000
2000
Interaction of C3b(2)--IgG complexes with complement proteins properdin, factor B and factor H: implications for amplification.
Nascent C3b can form ester bonds with various target molecules on the cell surface and in the fluid phase. Previously, we showed… (More)
  • figure 2
  • figure 1
  • figure 3
  • figure 4
  • figure 6
Is this relevant?
2000
2000
Properdin, the positive regulator of complement, is highly C-mannosylated.
Properdin is the positive regulator of the alternative pathway of complement activation. The 53-kDa protein is essentially… (More)
Is this relevant?
1994
1994
Expression of properdin in human monocytes.
Properdin is the only known positive regulator of the alternative pathway of complement activation. Northern blot analysis of… (More)
Is this relevant?
1989
1989
Analysis of the natural polymeric forms of human properdin and their functions in complement activation.
Many of the anomalies observed in studies or properdin may be explained on the basis of its ability to form a series of multi… (More)
Is this relevant?
1984
1984
Molecular architecture of human properdin, a positive regulator of the alternative pathway of complement.
The structure of the human properdin molecule was investigated by hydrodynamic, spectroscopic, and transmission electron… (More)
  • figure 1
  • figure 3
  • figure 4
  • figure 6
  • figure 5
Is this relevant?
1979
1979
Serum Complement Levels in Infancy: Age Related Changes
Summary: Levels of eight complement components and two control proteins, were determined on cord serum from normal full term… (More)
  • figure 1
  • table 2
Is this relevant?
1974
1974
Properdin factor D: characterization of its active site and isolation of the precursor form.
The activity of properdin factor D was measured by the generation of the hemolytically active cellular intermediate, EAC43B(D… (More)
Is this relevant?