• Publications
  • Influence
Retardation of fading and enhancement of intensity of immunofluorescence by p-phenylenediamine.
  • J. Platt, A. Michael
  • Chemistry, Medicine
  • The journal of histochemistry and cytochemistry…
  • 1 June 1983
TLDR
Visual and photometric comparison of tissue sections reacted sequentially with polyclonal or monoclonal antisera and appropriate fluorochromes and mounted with and without PD indicated that PD both prolonged and intensified fluorescence without evident effect on antibody binding. Expand
Selective deposition of immunoglobulin A1 in immunoglobulin A nephropathy, anaphylactoid purpura nephritis, and systemic lupus erythematosus.
To further characterize the IgA deposits found in glomeruli of patients with IgA nephropathy, anaphylactoid purpura nephritis, and systemic lupus erythematosus, renal biopsies from patients withExpand
Progressive encephalopathy in children with chronic renal insufficiency in infancy.
A retrospective analysis of children with renal failure during the first year of life revealed that 20 of 23 patients developed profound neurologic abnormalities. The encephalopathy was characterizedExpand
Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases.
TLDR
Four patients with type 1 diabetes mellitus received segmental pancreatic grafts and it is postulated that selective beta-cell destruction was a consequence of cell-mediated immunity leading to recurrent Diabetes mellitus. Expand
New form of X-linked dominant hereditary nephritis in dogs.
TLDR
This renal disease is an example of X-linked dominant HN, with typical abnormalities of GBM ultrastructure and alpha(IV) chain expression and dogs with this naturally acquired progressive renal disease can be used to investigate the pathogenesis and treatment of similar disorders in human beings and dogs. Expand
Recurrence of idiopathic nephrotic syndrome after renal transplantation.
TLDR
Subsequent kidney specimens after transplantation obtained from two of these patients with recurrent nephrotic syndrome showed focal segmental glomerulosclerosis limited primarily to the juxtamedullary glomeruli—a feature further suggesting recurrence of the original disease in the transplanted kidney, suggesting the pathogenesis of the steroid-resistant idiopathic nephRotic syndrome may involve systemic circulating factors. Expand
Polyantigenic Expansion of Basement Membrane Constituents in Diabetic Nephropathy
TLDR
The immunohistopathology of the intrinsic basement membrane-associated antigens were examined in diabetic nephropathy and document the complexity of polyantigenic alterations in the development of diabetic neephropathy. Expand
Human corneal basement membrane heterogeneity: topographical differences in the expression of type IV collagen and laminin isoforms.
TLDR
Investigating in detail corneal basement membrane (BM) composition and correlate it with the differentiation state of contributing cells found a novel type of spatial heterogeneity ("horizontal") in the EBM composition was found between the central cornea, limbus, and conjunctiva. Expand
Alport syndrome.
TLDR
People with Alport syndrome experience progressive loss of kidney function and develop high levels of protein in their urine, resulting in end-stage renal disease (ESRD). Expand
Renal disease in nail-patella syndrome: clinical and morphologic studies.
TLDR
The data presented suggest that the inborn error of connective tissue metabolism of the nail-patella syndrome is associated with renal disease as the result of deposition of collagen moieties in glomerular basement membranes with subsequent alterations ofglomerular structure and function. Expand
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