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Heparin is essential for the storage of specific granule proteases in mast cells
All mammals produce heparin, a negatively charged glycosaminoglycan that is a major constituent of the secretory granules of mast cells which are found in the peritoneal cavity and most connectiveExpand
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Differential expression of secretory granule proteases in mouse mast cells exposed to interleukin 3 and c-kit ligand
It is now established that the subclasses of mast cells (MC) that reside in mucosal and serosal environments can be distinguished from one another in terms of their expression of specific secretoryExpand
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Cooperative and antagonistic interplay between PU.1 and GATA-2 in the specification of myeloid cell fates.
PU.1 and GATA transcription factors appear to antagonize each other's function in the development of distinct lineages of the hematopoietic system. In contrast, we demonstrate that PU.1, like GATA-2,Expand
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GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene.
The transcription factors GATA-1, GATA-2, and GATA-3 were found to be expressed in several mouse and rat mast cell lines that contain mast cell carboxypeptidase A (MC-CPA) and other proteases inExpand
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Regulation of human eosinophil viability, density, and function by granulocyte/macrophage colony-stimulating factor in the presence of 3T3 fibroblasts
Normodense human peripheral blood eosinophils were isolated under sterile conditions from the 22/23 and 23/24% interfaces and the cell pellet of metrizamide gradients. After culture for 7 d in RPMIExpand
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Interleukin 3: A differentiation and growth factor for the mouse mast cell that contains chondroitin sulfate E proteoglycan.
Mouse mast cells were differentiated and grown by culturing bone marrow cells in medium containing 2 X 10(-10) M purified interleukin 3 (IL 3). The cells obtained were similar in ultrastructure,Expand
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Recent advances in the cellular and molecular biology of mast cells.
The mast cell is now considered to play a pivotal role not only in allergic reactions but also in a number of inflammatory disorders. After immunological activation via the IgE receptor, the mastExpand
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Evaluation of the Substrate Specificity of Human Mast Cell Tryptase βI and Demonstration of Its Importance in Bacterial Infections of the Lung*
Human pulmonary mast cells (MCs) express tryptases α and βI, and both granule serine proteases are exocytosed during inflammatory events. Recombinant forms of these tryptases were generated for theExpand
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Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing.
Mast cells (MCs) are active participants in blood coagulation and innate and acquired immunity. This review focuses on the development of mouse and human MCs, as well as the involvement of theirExpand
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RasGRP4, a New Mast Cell-restricted Ras Guanine Nucleotide-releasing Protein with Calcium- and Diacylglycerol-binding Motifs
  • Yi Yang, L. Li, +4 authors R. Stevens
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 12 July 2002
A cDNA was isolated from interleukin 3-developed, mouse bone marrow-derived mast cells (MCs) that contained an insert (designated mRasGRP4) that had not been identified in any species at the gene,Expand
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