Skip to search formSkip to main contentSkip to account menu

Prohormone Convertases

Known as: Convertase, Prohormone, Convertases, Prohormone, Prohormone Convertase 
National Institutes of Health

Related topics

Related topics

5 relations

Narrower (3)

Proprotein Convertase 1Proprotein Convertase 2paired basic amino acid cleaving enzyme

Broader (2)

Proprotein ConvertasesSerine Proteases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid.
Ghrelin was originally isolated from rat stomach as an endogenous ligand for the GH secretagogue receptor. The major active form… 
2004
2004
Altered Proglucagon Processing in an α-Cell Line Derived from Prohormone Convertase 2 Null Mouse Islets*
The endoproteolytic processing of proproteins in the secretory pathway depends on the expression of selected members of a family… 
Highly Cited
2001
Highly Cited
2001
Impaired Prohormone Convertases inCpe fat/Cpe fat Mice*
A spontaneous point mutation in the coding region of the carboxypeptidase E (CPE) gene results in a loss of CPE activity that… 
Highly Cited
2000
Highly Cited
2000
Defective Prodynorphin Processing in Mice Lacking Prohormone Convertase PC2
Abstract: Prodynorphin, a multifunctional precursor of several important opioid peptides, is expressed widely in the CNS. It is… 
2000
2000
Favourable side-chain orientation of cleavage site dibasic residues of prohormone in proteolytic processing by prohormone convertase 1/3.
Previous studies using selectively modified pro-ocytocin/neurophysin substrate analogues and the purified metalloprotease, pro… 
1999
1999
A 36-Residue Peptide Contains All of the Information Required for 7B2-mediated Activation of Prohormone Convertase 2*
The prohormone convertases (PCs) are serine proteinases responsible for the processing of secretory protein precursors. PC2 is… 
Highly Cited
1999
Highly Cited
1999
Proprotein Convertase Activity Contributes to the Processing of the Alzheimer's β‐Amyloid Precursor Protein in Human Cells: Evidence for a Role of the Prohormone Convertase PC7 in the Constitutive…
The physiological maturation of the beta-amyloid precursor protein (betaAPP) leads to the secretion of a fragment termed APPalpha… 
1998
1998
Localization of prohormone convertases 1/3 and 2 in the human pituitary gland and pituitary adenomas: analysis by immunohistochemistry, immunoelectron microscopy, and laser scanning microscopy.
Prohormone convertase (PC) 1/3 and PC2 are involved in post-translational processing of endocrine tissues, including the… 
1996
1996
Involvement of a Polyproline Helix-like Structure in the Interaction of 7B2 with Prohormone Convertase 2*
The neuroendocrine protein 7B2 is known to be involved in the biosynthesis and activity of prohormone convertase 2 (PC2… 
Highly Cited
1995
Highly Cited
1995
Enzymatic characterization of immunopurified prohormone convertase 2: potent inhibition by a 7B2 peptide fragment.
Prohormone convertase (PCs) are thought to mediate the controlled proteolysis of prohormones and neuropeptide precursors. While… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)