Prohormone Convertases

The islet of Langerhans is a highly vascularized micro-organ consisting of not only ß-cells but multiple cell types such as… Expand

CONTEXT Congenital deficiency of the neuroendocrine-specific enzyme prohormone convertase (PC) 1/3 leads to a syndrome… Expand

Islet amyloid, formed by aggregation of islet amyloid polypeptide (IAPP; amylin), is a pathological characteristic of the… Expand

Body weight is controlled by the activation of signal transduction pathways in both the brain and peripheral tissues… Expand

A spontaneous point mutation in the coding region of the carboxypeptidase E (CPE) gene results in a loss of CPE activity that… Expand

Five novel peptides were identified in the brains of mice lacking active carboxypeptidase E, a neuropeptide-processing enzyme… Expand

Prodynorphin, a multifunctional precursor of several important opioid peptides, is expressed widely in the CNS. It is processed… Expand

Although previous efforts to produce significant quantities of purified prohormone convertase 2 from either recombinant or… Expand

Proglucagon is processed differentially in the pancreatic alpha cells and the intestinal L cells to yield either glucagon or… Expand

The neuroendocrine polypeptide 7B2 is a highly conserved secretory protein selectively present in prohormone-producing cells… Expand