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Prohormone Convertases

Known as: Convertase, Prohormone, Convertases, Prohormone, Prohormone Convertase 
 

Topic mentions per year

Topic mentions per year

1991-2017
0102019912017

Related topics

Related topics

5 relations

Narrower (3)

Proprotein Convertase 1Proprotein Convertase 2paired basic amino acid cleaving enzyme

Broader (2)

Proprotein ConvertasesSerine Proteases

Related mentions per year

Related mentions per year

1969-2018
1960198020002020
Prohormone Convertases
Serine Proteases
paired basic amino acid cleaving enzyme
Proprotein Convertases
Proprotein Convertase 2
Proprotein Convertase 1

Papers overview

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Highly Cited
2007
Highly Cited
2007
Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3.
CONTEXT Congenital deficiency of the neuroendocrine-specific enzyme prohormone convertase (PC) 1/3 leads to a syndrome… (More)
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2006
2006
Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death.
Islet amyloid, formed by aggregation of islet amyloid polypeptide (IAPP; amylin), is a pathological characteristic of the… (More)
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2001
2001
Impaired prohormone convertases in Cpe(fat)/Cpe(fat) mice.
A spontaneous point mutation in the coding region of the carboxypeptidase E (CPE) gene results in a loss of CPE activity that… (More)
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2001
2001
The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site.
Impaired processing of pro-islet amyloid polypeptide (proIAPP), the precursor of the beta-cell peptide islet amyloid polypeptide… (More)
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2000
2000
Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing.
Five novel peptides were identified in the brains of mice lacking active carboxypeptidase E, a neuropeptide-processing enzyme… (More)
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Highly Cited
1995
Highly Cited
1995
Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide.
Proglucagon is processed differently in the islet alpha cells and the intestinal endocrine L cells to release either glucagon or… (More)
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1994
1994
Endoproteolytic processing of proopiomelanocortin and prohormone convertases 1 and 2 in neuroendocrine cells overexpressing prohormone convertases 1 or 2.
AtT-20 mouse corticotrope tumor cell lines overexpressing the prohormone convertases PC1 or PC2 were established and used to… (More)
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1994
1994
7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway.
The neuroendocrine polypeptide 7B2 is a highly conserved secretory protein selectively present in prohormone-producing cells… (More)
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1993
1993
Purification and characterization of the prohormone convertase PC1(PC3).
The prohormone convertases PC1 (also known as PC3) and PC2 have been implicated in the biosynthesis of several polypeptide… (More)
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1991
1991
Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary…
Using a 796-basepair cDNA fragment obtained from a mouse pituitary library we have screened two mouse insulinoma libraries and… (More)
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