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paired basic amino acid cleaving enzyme

Known as: Furin Preproprotein, SPC1 Proteinase, Paired Basic Amino Acid Residue-Cleaving Enzyme 
A proprotein convertase with specificity for the proproteins of PROALBUMIN; COMPLEMENT 3C; and VON WILLEBRAND FACTOR. It has specificity for cleavage… 
National Institutes of Health

Related topics

Related topics

19 relations
Enzyme GeneFURIN geneHydrolysisIn Blood

Broader (2)

Prohormone ConvertasesSerine Endopeptidases

Papers overview

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Highly Cited
2003
Highly Cited
2003
The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis.
The secretory factor VEGF-C has been directly implicated in various physiological processes during embryogenesis and human… 
Highly Cited
2000
Highly Cited
2000
Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertases.
Membrane type-1 matrix metalloproteinase (MT1-MMP) is the prototypical member of a subgroup of membrane-anchored proteinases that… 
Highly Cited
2000
Highly Cited
2000
A Furin-like Convertase Mediates Propeptide Cleavage of BACE, the Alzheimer's β-Secretase*
The novel transmembrane aspartic protease BACE (for Beta-site APP CleavingEnzyme) is the β-secretase that cleaves amyloid… 
Highly Cited
1996
Highly Cited
1996
Membrane-type matrix metalloproteinase 1 is a gelatinolytic enzyme and is secreted in a complex with tissue inhibitor of metalloproteinases 2.
The processing mechanism and gelatinolytic activity of the membrane-type matrix metalloproteinase 1 (MT-MMP-1) were examined by… 
Review
1994
Review
1994
The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.
Highly Cited
1992
Highly Cited
1992
Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3.
Experiments using recombinant vaccinia viruses expressing rat proinsulin I coinfected into COS-7 cells with recombinant vaccinia… 
Review
1991
Review
1991
Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway.
Highly Cited
1991
Highly Cited
1991
Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary…
Using a 796-basepair cDNA fragment obtained from a mouse pituitary library we have screened two mouse insulinoma libraries and… 
Highly Cited
1991
Highly Cited
1991
Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.
PC2 and furin are two recently identified members of a class of mammalian proteins homologous to the yeast precursor processing… 
Highly Cited
1990
Highly Cited
1990
cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.
ABSTRACT Based on the concept of sequence conservation around the active sites of serine proteinases, polymerase chain reaction… 
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