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FURIN gene

Known as: Furin (Paired Basic Amino Acid Cleaving Enzyme) Gene, FUR, PAIRED BASIC AMINO ACID CLEAVING ENZYME 
This gene plays a role in cell-cell signaling and signal transduction.
National Institutes of Health

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FURIN wt Allele
HydrolysisPost-Translational Protein ProcessingProteolysisProteolytic Processing

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Dysregulation of FURIN by prostaglandin‐endoperoxide synthase 2 in lung epithelial NCI‐H292 cells
Because proprotein convertases (PCSKs) activate growth factors and matrix metalloproteinase, these enzymes have been implicated… 
2008
2008
Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7
Background and aims: Hepcidin is an iron homoeostasis regulator peptide. Loss-of-function mutations cause juvenile… 
2008
2008
Interaction of Mint3 with Furin regulates the localization of Furin in the trans-Golgi network
Furin is a proprotein convertase that cycles between the plasma membrane, endosomes and the trans-Golgi network (TGN… 
Highly Cited
2007
Highly Cited
2007
Atf1 is a target of the mitogen-activated protein kinase Pmk1 and regulates cell integrity in fission yeast.
In fission yeast, knockout of the calcineurin gene resulted in hypersensitivity to Cl(-), and the overexpression of pmp1… 
2007
2007
RNA‐binding protein Csx1 is phosphorylated by LAMMER kinase, Lkh1, in response to oxidative stress in Schizosaccharomyces pombe
2002
2002
Furin gene (fur) regulation in differentiating human megakaryoblastic Dami cells: involvement of the proximal GATA recognition motif in the P1 promoter and impact on the maturation of furin…
The convertase furin is involved in the maturation of key growth/aggregation mediators synthesized by the platelet producers… 
2000
2000
Comparative characterization of two forms of recombinant human SPC1 secreted from Schneider 2 cells.
SPC1 (furin/PACE), an enzyme belonging to the S8 group of serine endoproteases, is a type I integral membrane protein that… 
Highly Cited
1997
Highly Cited
1997
Protein Phosphatase 2C Acts Independently of Stress-activated Kinase Cascade to Regulate the Stress Response in Fission Yeast*
Stress-activated signal transduction pathways, which are largely conserved among a broad spectrum of eukaryotic species, have a… 
1995
1995
Processing of human factor I in COS-1 cells co-transfected with factor I and paired basic amino acid cleaving enzyme (PACE) cDNA.
1995
1995
Proprotein convertases in amphioxus: predicted structure and expression of proteases SPC2 and SPC3.
SPC2 and SPC3 are two members of a family of subtilisin-related proteases which play essential roles in the processing of… 
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