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Bone marrow-derived Gr1+ cells can generate a metastasis-resistant microenvironment via induced secretion of thrombospondin-1.
TLDR
A 5-amino acid peptide with Tsp-1–inducing activity was identified as a therapeutic agent against metastatic cancer and developed as a pharmacologic inducer of TSp-1 in Gr1(+) bone marrow cells, which dramatically suppressed metastasis.
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Interaction of Mint3 with Furin regulates the localization of Furin in the trans-Golgi network
TLDR
It is shown that Mint3 interacts with Furin in the Golgi compartment of HeLa cells and the interaction between the PTB domain of Mint3 and the acidic peptide signal of Furin regulates the specific localization of Fur in the trans-Golgi network.
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GRK3 is essential for metastatic cells and promotes prostate tumor progression
TLDR
It is discovered that G-protein–coupled receptor kinase 3 (GRK3) was not only necessary for survival and proliferation of metastatic cells, but also sufficient to promote primary prostate tumor growth and metastasis upon exogenous expression in poorly metastasis cells in mouse xenograft models.
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Development of a prosaposin-derived therapeutic cyclic peptide that targets ovarian cancer via the tumor microenvironment
TLDR
A cyclic peptide with drug-like properties derived from the active sequence in psap was developed and promoted tumor regression in a patient-derived tumor xenograft model of metastatic ovarian cancer, suggesting that this peptide is a candidate for future testing in human patients.
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Abstract 4584: Bone marrow-derived Gr1+ cells can generate a metastasis-resistant microenvironment via induced secretion of thrombospondin-1.
TLDR
Clinically, examination of a tumor tissue microarray (TMA) compiled from 103 prostate cancer patients with long and complete follow up, revealed that prosaposin expression positively correlated with increased overall survival, suggesting that the prosapOSin peptide may be a potential therapeutic agent against metastatic cancer.
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mr1e, a conotoxin from Conus marmoreus with a novel disulfide pattern.
TLDR
The identification of a novel conotoxin named mr1e from Conus marmoreus, composed of 11 amino acid residues cross-linked by two disulfide bonds, which enriches the understanding of conotoxins, and opens an avenue for further structural and functional investigation.
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CCL5 derived from platelets increases megakaryocyte proplatelet formation.
TLDR
It is proposed that CCL5 signaling through CCR5 may increase platelet counts during physiological stress and influence proplatelet production by suppressing apoptosis.
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Iron chelators increase the resistance of Ataxia telangeictasia cells to oxidative stress.
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Iron chelators reduce chromosomal breaks in ataxia-telangiectasia cells.
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Desferrioxamine treatment increases the genomic stability of Ataxia-telangiectasia cells.
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