Proteolytic Processing

Known as: Proteolytic Clipping 
Generally irreversible, Proteolytic Processing involves removal of peptide segments from proteins, usually from the N- or C-terminus and often during… (More)
National Institutes of Health

Papers overview

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Review
2012
Review
2012
Accumulations of insoluble deposits of amyloid β-peptide are major pathological hallmarks of Alzheimer disease. Amyloid β-peptide… (More)
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Highly Cited
2006
Highly Cited
2006
Many muscular and neurological disorders are associated with mitochondrial dysfunction and are often accompanied by changes in… (More)
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Highly Cited
1999
Highly Cited
1999
The recombinant form of the proapoptotic caspase-9 purified following expression in Escherichia coli is processed at Asp315, but… (More)
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Highly Cited
1997
Highly Cited
1997
The recently identified vascular endothelial growth factor C (VEGF-C) belongs to the platelet-derived growth factor (PDGF)/VEGF… (More)
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Highly Cited
1997
Highly Cited
1997
The semaphorins are a large group of cell surface and secreted proteins implicated in axonal pathfinding. Here we show that the… (More)
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Highly Cited
1996
Highly Cited
1996
Previous studies imply that the intracellular domain of Notch1 must translocate to the nucleus for its activity. In this study… (More)
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Highly Cited
1995
Highly Cited
1995
Sonic hedgehog (Shh) is expressed in tissues with known signalling capacities, such as the notochord, the floor plate of the… (More)
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Highly Cited
1994
Highly Cited
1994
The proteolytic cleavages at the NS3-NS4A, NS4A-NS4B, NS4B-NS5A, and NS5A-NS5B junctions of hepatitis C virus (HCV) polyprotein… (More)
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Highly Cited
1993
Highly Cited
1993
By using a plasmid-based transient protein expression system in cultured cells and an in vitro transcription/translation system… (More)
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Highly Cited
1992
Highly Cited
1992
The 4-kilodalton (39 to 43 amino acids) amyloid beta protein (beta AP), which is deposited as amyloid in the brains of patients… (More)
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