BACE1 wt Allele

Known as: BACE, Secretase, Beta Gene, HSPC104 
Human BACE1 wild-type allele is located within 11q23.2-q23.3 and is approximately 31 kb in length. This allele, which encodes beta-secretase 1… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
OBJECTIVE An estimated 200 million patients worldwide have surgery each year. Anesthesia and surgery have been reported to… (More)
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Highly Cited
2007
Highly Cited
2007
Beta-site APP-cleaving enzyme (BACE) is required for production of the Alzheimer's disease (AD)-associated Abeta protein. BACE… (More)
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Highly Cited
2007
Highly Cited
2007
Evidence suggests that beta-amyloid (Abeta) peptide triggers a pathogenic cascade leading to neuronal loss in Alzheimer's disease… (More)
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Highly Cited
2005
Highly Cited
2005
The beta-secretase, BACE, is a membrane spanning aspartic protease, which cleaves the amyloid precursor protein (APP) in the… (More)
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Review
2004
Review
2004
In 1959, Dave Brubeck and Paul Desmond revolutionized modern jazz music by composing their unforgettable Take Five in 5/4, one of… (More)
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Highly Cited
2004
Highly Cited
2004
Whether elevated beta-secretase (BACE) activity is related to plaque formation or amyloid beta peptide (Abeta) production in… (More)
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Highly Cited
2003
Highly Cited
2003
To the editor—A critical feature of Alzheimer disease (AD) is the deposition of plaque, which contains high levels of amyloid… (More)
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Highly Cited
2003
Highly Cited
2003
Amyloid-beta peptide, which accumulates in senile plaques in Alzheimer's disease, is derived from the amyloid precursor protein… (More)
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Highly Cited
2002
Highly Cited
2002
Recently an aspartyl protease with beta-secretase activity called BACE was identified. In the present paper we showed that BACE… (More)
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Highly Cited
1999
Highly Cited
1999
Cerebral deposition of amyloid beta peptide (Abeta) is an early and critical feature of Alzheimer's disease. Abeta generation… (More)
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