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BACE1 wt Allele

Known as: BACE, Secretase, Beta Gene, HSPC104 
Human BACE1 wild-type allele is located within 11q23.2-q23.3 and is approximately 31 kb in length. This allele, which encodes beta-secretase 1… 
National Institutes of Health

Related topics

Related topics

5 relations
11q23.2-q23.3Alzheimer's Disease Pathway KEGGHydrolysisProteolysis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Functions of the Alzheimer’s Disease Protease BACE1 at the Synapse in the Central Nervous System
Inhibition of the protease β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is a promising treatment strategy for… 
2010
2010
In vitro antiamyloidogenic properties of 1,4-naphthoquinones.
Highly Cited
2008
Highly Cited
2008
Impact of cholesterol level upon APP and BACE proximity and APP cleavage.
Highly Cited
2005
Highly Cited
2005
Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics.
Molecular modeling based on the X-ray crystal structure of the Tang-Ghosh heptapeptide inhibitor 1 (OM99-2) of BACE led to the… 
Review
2005
Review
2005
Expression and activity of β-site amyloid precursor protein cleaving enzyme in Alzheimer's disease
Several lines of evidence indicate that the Aβ peptide is involved at some level in the pathological process that results in the… 
Highly Cited
2004
Highly Cited
2004
Increased beta-secretase activity and expression in rats following transient cerebral ischemia.
The aberrant proteolytic processing of the amyloid precursor protein (APP) by beta- and gamma-secretases is key to amyloid plaque… 
2004
2004
beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice…
The generation of amyloid peptides (Abeta) from the amyloid precursor protein (APP) is initiated by beta-secretase (BACE… 
2003
2003
Measuring human beta-secretase (BACE1) activity using homogeneous time-resolved fluorescence.
2003
2003
Secretion and intracellular generation of truncated Abeta in beta-site amyloid-beta precursor protein-cleaving enzyme expressing human neurons.
Insoluble pools of the amyloid-beta peptide (Abeta) in brains of Alzheimer's disease patients exhibit considerable N- and C… 
Highly Cited
2001
Highly Cited
2001
Three novel alternatively spliced isoforms of the human beta-site amyloid precursor protein cleaving enzyme (BACE) and their effect on amyloid beta-peptide production
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