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BACE1 wt Allele

Known as: BACE, Secretase, Beta Gene, HSPC104 
Human BACE1 wild-type allele is located within 11q23.2-q23.3 and is approximately 31 kb in length. This allele, which encodes beta-secretase 1… 
National Institutes of Health

Related topics

Related topics

5 relations
11q23.2-q23.3Alzheimer's Disease Pathway KEGGHydrolysisProteolysis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
BACE1 Deficiency Causes Altered Neuronal Activity and Neurodegeneration
BACE1 is required for the release of β-amyloid (Aβ) in vivo, and inhibition of BACE1 activity is targeted for reducing A… 
Highly Cited
2008
Highly Cited
2008
Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice
β-Site APP-cleaving enzyme 1 (BACE1) is required for the penultimate cleavage of the amyloid-β precursor protein (APP) leading to… 
Highly Cited
2008
Highly Cited
2008
Transcriptional Regulation of β-Secretase by p25/cdk5 Leads to Enhanced Amyloidogenic Processing
Highly Cited
2005
Highly Cited
2005
The Low Density Lipoprotein Receptor-related Protein (LRP) Is a Novel β-Secretase (BACE1) Substrate*
BACE is a transmembrane protease with β-secretase activity that cleaves the amyloid precursor protein (APP). After BACE cleavage… 
Highly Cited
2004
Highly Cited
2004
Take five—BACE and the γ‐secretase quartet conduct Alzheimer's amyloid β‐peptide generation
In 1959, Dave Brubeck and Paul Desmond revolutionized modern jazz music by composing their unforgettable Take Five in 5/4, one of… 
Highly Cited
2004
Highly Cited
2004
Neuronal membrane cholesterol loss enhances amyloid peptide generation
Recent experimental and clinical retrospective studies support the view that reduction of brain cholesterol protects against… 
Review
2004
Review
2004
Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.
In 1959, Dave Brubeck and Paul Desmond revolutionized modern jazz music by composing their unforgettable Take Five in 5/4, one of… 
Highly Cited
2003
Highly Cited
2003
Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes
Amyloid-β peptide, which accumulates in senile plaques in Alzheimer's disease, is derived from the amyloid precursor protein (APP… 
Highly Cited
2002
Highly Cited
2002
Substrate and Inhibitor Profile of BACE (β-Secretase) and Comparison with Other Mammalian Aspartic Proteases*
The full-length and ectodomain forms of β-site APP cleavage enzyme (BACE) have been cloned, expressed in Sf9 cells, and purified… 
Highly Cited
2001
Highly Cited
2001
Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain
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