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Neuroblastoma × spinal cord (NSC) hybrid cell lines resemble developing motor neurons
We have developed a series of mouse‐mouse neural hybrid cell lines by fusing the aminopterin‐sensitive neuroblastoma N18TG2 with motor neuron‐enriched embryonic day 12–14 spinal cord cells. Of 30Expand
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Chronic Stress Induces Impairment of Spatial Working Memory Because of Prefrontal Dopaminergic Dysfunction
Although the mechanism responsible for cognitive deficits in stress-related neuropsychiatric disorders has been obscure, prefrontal cortical (PFC) dopaminergic dysfunction is thought to be involved.Expand
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Regulation of Experimental Autoimmune Encephalomyelitis by Natural Killer (NK) Cells
In this report, we establish a regulatory role of natural killer (NK) cells in experimental autoimmune encephalomyelitis (EAE), a prototype T helper cell type 1 (Th1)-mediated disease. ActiveExpand
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Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cells.
Radioiodinated erythropoietin (Epo) was bound specifically to the cells of two non-erythroid clonal lines, PC12 and SN6, which expressed neuronal characteristics. The binding was time-, cell number-,Expand
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Chronic stress attenuates glucocorticoid negative feedback: involvement of the prefrontal cortex and hippocampus
Disruption of the glucocorticoid negative feedback system is observed in approximate one half of human depressives, and a similar condition is induced in animals by chronic stress. This disruption isExpand
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Frequency of tau gene mutations in familial and sporadic cases of non-Alzheimer dementia.
BACKGROUND Mutations in the tau gene have been reported in families with frontotemporal dementia (FTD) linked to chromosome 17. It remains uncertain how commonly such mutations are found in patientsExpand
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A molecular chaperone inducer protects neurons from ER stress
The endoplasmic reticulum (ER) stress response is a defense system for dealing with the accumulation of unfolded proteins in the ER lumen. Recent reports have shown that ER stress is involved in theExpand
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Tissue preconditioning may explain concentric lesions in Baló's type of multiple sclerosis.
Lesions of Baló's concentric sclerosis are characterized by alternating layers of myelinated and demyelinated tissue. The reason for concentric demyelination in this variant of multiple sclerosis isExpand
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Changes in brain morphology in Alzheimer disease and normal aging: is Alzheimer disease an exaggerated aging process?
BACKGROUND AND PURPOSE Whether Alzheimer disease (AD) represents exaggerated aging rather than a disease is controversial. Data about the effects of normal aging on the human brain are essential forExpand
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Genetic, clinical and pathological studies of CADASIL in Japan: a partial contribution of Notch3 mutations and implications of smooth muscle cell degeneration for the pathogenesis
We have examined Notch3 mutations in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) whose samples were submitted to us in Japan.Expand
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