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Neuroblastoma × spinal cord (NSC) hybrid cell lines resemble developing motor neurons
TLDR
A series of mouse‐mouse neural hybrid cell lines developed by fusing the aminopterin‐sensitive neuroblastoma N18TG2 with motor neuron‐enriched embryonic day 12–14 spinal cord cells appear to model selected aspects of motor neuron development in an immortalized clonal system. Expand
Chronic Stress Induces Impairment of Spatial Working Memory Because of Prefrontal Dopaminergic Dysfunction
TLDR
Results indicate that chronic stress induces working memory impairment through a D1 receptor-mediated hypodopaminergic mechanism in the PFC, and provides important information for understanding of the mechanisms underlying PFC dysfunction in stress-related neuropsychiatric disorders. Expand
Regulation of Experimental Autoimmune Encephalomyelitis by Natural Killer (NK) Cells
TLDR
It is concluded that NK cells are an important regulator for EAE in both induction and effector phases, and it is shown thatNK cells inhibit T cell proliferation triggered by antigen or cytokine stimulation. Expand
Chronic cerebral hypoperfusion induced by right unilateral common carotid artery occlusion causes delayed white matter lesions and cognitive impairment in adult mice
TLDR
A novel mouse model of VaD with WM lesions, induced by right unilateral common carotid artery occlusion (rUCCAO), is developed and suggests that this model is a useful tool for investigating the associations among inflammatory reactions, cognitive impairment, and WM damage, which may help elucidating the pathomechanism ofVaD, particularly SIVD. Expand
Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cells.
TLDR
The binding of Epo to PC12 cells caused a rapid increase in the cytosolic concentration of free calcium, indicating that Epo stimulated the calcium influx from outside of the cells. Expand
Chronic stress attenuates glucocorticoid negative feedback: involvement of the prefrontal cortex and hippocampus
TLDR
The results suggest that the abnormal changes in GRs in the higher centers of the hypothalamo-pituitary-adrenal axis are involved in the chronic stress-induced attenuation of the feedback. Expand
A molecular chaperone inducer protects neurons from ER stress
TLDR
It appears that BIX induces BiP to prevent neuronal death by ER stress, suggesting that it may be a potential therapeutic agent for cerebral diseases caused by ER Stress. Expand
Frequency of tau gene mutations in familial and sporadic cases of non-Alzheimer dementia.
TLDR
It is concluded that tau mutations are uncommon in a neurology referral population with non-Alzheimer dementia, even in those with a clinical diagnosis of FTD, although a positive family history and/or tau pathologic findings increase the likelihood of a tau mutation. Expand
Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation
TLDR
It is found that neurodegeneration was significantly accelerated in mice older than 13 months (aged mice) with familial Alzheimer disease mutant PS-1, without amyloid plaque formation, but there were significantly more neurons containing intracellularly deposited Aβ42 in aged mutant transgenic mice. Expand
FTDP‐17 mutations N279K and S305N in tau produce increased splicing of exon 10
TLDR
It is shown that the recently identified FTDP‐17 missense mutations N279K and S305N do not reduce the ability of tau to promote microtubule assembly, but instead they lead to increased splicing of exon 10, like the intronic mutations. Expand
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