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A proteomic view of the Plasmodium falciparum life cycle
The completion of the Plasmodium falciparum clone 3D7 genome provides a basis on which to conduct comparative proteomics studies of this human pathogen. Here, we applied a high-throughput proteomicsExpand
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Discovery of Gene Function by Expression Profiling of the Malaria Parasite Life Cycle
The completion of the genome sequence for Plasmodium falciparum, the species responsible for most malaria human deaths, has the potential to reveal hundreds of new drug targets and proteins involvedExpand
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A Conserved Molecular Motor Drives Cell Invasion and Gliding Motility across Malaria Life Cycle Stages and Other Apicomplexan Parasites*
Apicomplexan parasites constitute one of the most significant groups of pathogens infecting humans and animals. The liver stage sporozoites of Plasmodium spp. and tachyzoites of Toxoplasma gondii,Expand
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Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle.
To investigate the role of post-transcriptional controls in the regulation of protein expression for the malaria parasite, Plasmodium falciparum, we have compared mRNA transcript and proteinExpand
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A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion- inhibiting antibodies
A complex of polypeptides derived from a precursor is present on the surface of the malaria merozoite. During erythrocyte invasion only a small fragment from this complex is retained on the parasiteExpand
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The Motor Complex of Plasmodium falciparum
Calcium-dependent protein kinases (CDPKs) of Apicomplexan parasites are crucial for the survival of the parasite throughout its life cycle. CDPK1 is expressed in the asexual blood stages of theExpand
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A comprehensive evaluation of rodent malaria parasite genomes and gene expression
BackgroundRodent malaria parasites (RMP) are used extensively as models of human malaria. Draft RMP genomes have been published for Plasmodium yoelii, P. berghei ANKA (PbA) and P. chabaudi AS (PcAS).Expand
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Dual acylation of the 45 kDa gliding-associated protein (GAP45) in Plasmodium falciparum merozoites.
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Epigenetic Silencing of Plasmodium falciparum Genes Linked to Erythrocyte Invasion
The process of erythrocyte invasion by merozoites of Plasmodium falciparum involves multiple steps, including the formation of a moving junction between parasite and host cell, and it isExpand
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A Role for the Protease Falcipain 1 in Host Cell Invasion by the Human Malaria Parasite
Cysteine proteases of Plasmodium falciparum are required for survival of the malaria parasite, yet their specific cellular functions remain unclear. We used a chemical proteomic screen with aExpand
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