• Publications
  • Influence
Intensity-based hierarchical Bayes method improves testing for differentially expressed genes in microarray experiments
BackgroundThe small sample sizes often used for microarray experiments result in poor estimates of variance if each gene is considered independently. Yet accurately estimating variability of geneExpand
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Interleukin-5 Expression in the Lung Epithelium of Transgenic Mice Leads to Pulmonary Changes Pathognomonic of Asthma
We have generated transgenic mice that constitutively express murine interleukin (IL)-5 in the lung epithelium. Airway expression of this cytokine resulted in a dramatic accumulation of peribronchialExpand
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LRpath: a logistic regression approach for identifying enriched biological groups in gene expression data
MOTIVATION The elucidation of biological pathways enriched with differentially expressed genes has become an integral part of the analysis and interpretation of microarray data. Several statisticalExpand
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O3-induced change in bronchial reactivity to methacholine and airway inflammation in humans.
The increase in airway responsiveness induced by O3 exposure in dogs is associated with airway epithelial inflammation, as evidenced by an increase in the number of neutrophils (polymorphonuclearExpand
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Gene expression profiling of the early pulmonary response to hyperoxia in mice.
To identify molecular events occurring during the early response to hyperoxia, we measured changes over time in total lung gene expression in C57BL/6 mice during prolonged exposure to > 95% O2.Expand
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Regulation of human airway mucins by acrolein and inflammatory mediators.
Bronchitis, asthma, and cystic fibrosis, marked by inflammation and mucus hypersecretion, can be caused or exacerbated by airway pathogens or irritants including acrolein, an aldehyde present inExpand
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Hazardous air pollutants and asthma.
  • G. Leikauf
  • Medicine
  • Environmental health perspectives
  • 14 February 2002
Asthma has a high prevalence in the United States, and persons with asthma may be at added risk from the adverse effects of hazardous air pollutants (HAPs). Complex mixtures (fine particulate matterExpand
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Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs
Mesenchymal stem cells (MSCs) and macrophages are fundamental components of the stem cell niche and function coordinately to regulate haematopoietic stem cell self-renewal and mobilization. RecentExpand
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Zinc deficiency increases organ damage and mortality in a murine model of polymicrobial sepsis*
Objective: Zinc deficiency is common among populations at high risk for sepsis mortality, including elderly, alcoholic, and hospitalized patients. Zinc deficiency causes exaggerated inflammatoryExpand
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Ozone inhalation stimulates expression of a neutrophil chemotactic protein, macrophage inflammatory protein 2.
Short-term exposure of humans and animals to ozone results in increased lung neutrophils; however, the mechanisms underlying this response are not completely understood. We examined the potentialExpand
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