Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.

@article{Smeekens1991IdentificationOA,
  title={Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.},
  author={S. P. Smeekens and A S Avruch and J N LaMendola and Shu Jin Chan and Donald F. Steiner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 2},
  pages={340-4}
}
PC2 and furin are two recently identified members of a class of mammalian proteins homologous to the yeast precursor processing protease kex2 and the bacterial subtillisins. We have used the polymerase chain reaction to identify and clone a cDNA (PC3) from the mouse AtT20 anterior pituitary cell line that represents an additional member of this growing family of mammalian proteases. PC3 encodes a 753-residue protein that begins with a signal peptide and contains a 292-residue domain closely… CONTINUE READING
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