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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
TLDR
Two mutations in the gene PCSK9 (encoding proprotein convertase subtilisin/kexin type 9) that cause ADH are reported, a newly identified human subtilase that is highly expressed in the liver and contributes to cholesterol homeostasis.
The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): Liver regeneration and neuronal differentiation
TLDR
The properties of a proteinase K-like subtilase, neural apoptosis-regulated convertase 1 (NARC-1), representing the ninth member of the secretory subtilases family, are described, suggesting that NARC- 1 is implicated in the differentiation of cortical neurons.
The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade
TLDR
A peculiar furin-like cleavage site is identified in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs, and its potential implication in the development of antivirals is discussed.
Chloroquine is a potent inhibitor of SARS coronavirus infection and spread
TLDR
Chloroquine is effective in preventing the spread of SARS CoV in cell culture and the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds.
The Notch1 receptor is cleaved constitutively by a furin-like convertase.
TLDR
The results confirm and extend recent reports indicating that the Notch receptor exists at the plasma membrane as a heterodimeric molecule, but disagree as to the nature of the protease that is responsible for the cleavage that takes place in the extracellular region.
Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides 1 Published on the World Wide Web on 17 August 1999. 1
TLDR
While PCs are responsible for the processing of neuropeptides, adhesion molecules, receptors, growth factors, cell surface glycoprotein and enzymes, SKI-1 cleaves proproteins that are critical for the control of cholesterol and fatty acid metabolism and for neuronal protection and growth.
The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P
TLDR
It is shown here that GP-C is cleaved in the endoplasmic reticulum by the cellular subtilase SKI-1/S1P, an enzyme that has so far been observed to be involved in cholesterol metabolism.
The biology and therapeutic targeting of the proprotein convertases
TLDR
The physiological functions and pathological implications of the proprotein convertases are summarized, proposed strategies to control some of their activities are discussed, and their therapeutic application and validation in selected disease states are discussed.
Translational control of hippocampal synaptic plasticity and memory by the eIF2α kinase GCN2
TLDR
This study provides genetic, physiological, behavioural and molecular evidence that GCN2 regulates synaptic plasticity, as well as learning and memory, through modulation of the ATF4/CREB pathway.
Biosynthesis and Post-translational Processing of the Precursor to Brain-derived Neurotrophic Factor*
TLDR
The biosynthesis and post-translational processing of the brain-derived neurotrophic factor precursor (pro-BDNF) in cells infected with a pro-BD NF-encoding vaccinia virus is examined to suggest that 28-kDa pro- BDNF is not an obligatory intermediate in the formation of the 14-k da form in the constitutive secretory pathway.
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