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Proprotein Convertase 2

Known as: PC2 Protein, Endoprotease, PC2, Prohormone Convertase, PC2 
A serine endopeptidase that has specificity for cleavage at ARGININE. It cleaves a variety of prohormones including PRO-OPIOMELANOCORTIN… 
National Institutes of Health

Related topics

Related topics

11 relations
In BloodPCSK2 geneProcess of secretionantagonists & inhibitors

Broader (2)

Prohormone ConvertasesProprotein Convertases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2000
Highly Cited
2000
Defective Prodynorphin Processing in Mice Lacking Prohormone Convertase PC2
Abstract: Prodynorphin, a multifunctional precursor of several important opioid peptides, is expressed widely in the CNS. It is… 
Highly Cited
1999
Highly Cited
1999
Long-term elevation of free fatty acids leads to delayed processing of proinsulin and prohormone convertases 2 and 3 in the pancreatic beta-cell line MIN6.
To explore the role of chronically elevated free fatty acids (FFAs) in the pathogenesis of the hyperproinsulinemia of type 2… 
Highly Cited
1996
Highly Cited
1996
Identification of a Transferable Sorting Domain for the Regulated Pathway in the Prohormone Convertase PC2*
The mammalian subtilisin-like endoproteases furin and PC2 catalyze similar reactions but in different parts of the cell: furin in… 
Highly Cited
1996
Highly Cited
1996
The effects of peroxisome proliferators on protein abundances in mouse liver.
We have investigated the effects of five peroxisome proliferators (PPs : clofibric acid, DEHP, WY14,643, nafenopin, and LY171883… 
Highly Cited
1995
Highly Cited
1995
Comparative proteolytic processing of rat prosomatostatin by the convertases PC1, PC2, furin, PACE4 and PC5 in constitutive and regulated secretory pathways
Highly Cited
1994
Highly Cited
1994
Developmental expression of the prohormone convertases PC1 and PC2 in mouse pancreatic islets.
The immunocytochemical distribution and messenger RNA expression of the prohormone convertases PC1 and PC2 involved in the… 
Highly Cited
1993
Highly Cited
1993
Gene expression of prohormone and proprotein convertases in the rat CNS: a comparative in situ hybridization analysis
Posttranslational processing of proproteins and prohormones is an essential step in the formation of bioactive peptides, which is… 
Highly Cited
1993
Highly Cited
1993
Heterologous processing of prosomatostatin in constitutive and regulated secretory pathways. Putative role of the endoproteases furin, PC1, and PC2.
Highly Cited
1991
Highly Cited
1991
Identification of kex2-related proteases in chromaffin granules by partial amino acid sequence analysis.
Highly Cited
1990
Highly Cited
1990
Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells.
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