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Proprotein Convertases

Known as: Convertase, Proprotein, Proprotein Convertase, Proprotein Convertases [Chemical/Ingredient] 
Proteolytic enzymes that are involved in the conversion of protein precursors such as peptide prohormones into PEPTIDE HORMONES. Some are… 
National Institutes of Health

Related topics

Related topics

14 relations
In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects

Narrower (6)

Pro-Opiomelanocortin Converting EnzymeProhormone ConvertasesProprotein Convertase 2Subtilisin-Like Proprotein Convertases

Papers overview

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Highly Cited
2012
Highly Cited
2012
Role of proprotein convertases in prostate cancer progression.
Better understanding of the distinct and redundant functions of the proprotein convertase (PC) enzyme family within… 
Review
2008
Review
2008
Knock-out mouse models of proprotein convertases: unique functions or redundancy?
The members of the proprotein convertase family play a central role in the processing and/or activation of various protein… 
2008
2008
Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7
Background and aims: Hepcidin is an iron homoeostasis regulator peptide. Loss-of-function mutations cause juvenile… 
2005
2005
Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases
BackgroundThe family of proprotein convertases has been recently implicated in tumorigenesis and metastasis in animal models… 
2004
2004
Drosophila Serpin 4 Functions as a Neuroserpin-Like Inhibitor of Subtilisin-Like Proprotein Convertases
The proteolytic processing of neuropeptide precursors is believed to be regulated by serine proteinase inhibitors, or serpins… 
2003
2003
Proprotein convertases regulate activity of prostate epithelial cell differentiation markers and are modulated in human prostate cancer cells
Prostate derived factor (PDF) is a member of transforming growth factor‐β (TGF‐β) superfamily proteins involved in… 
Highly Cited
1998
Highly Cited
1998
Proprotein Convertase PC1/3-related Peptides Are Potent Slow Tight-binding Inhibitors of Murine PC1/3 and Hfurin*
The proprotein convertase PC1/3 belongs to the subtilisin/kexin-like endoprotease family and is synthesized as a preproenzyme. To… 
1998
1998
Testis-Specific Prohormone Convertase PC4 Processes the Precursor of Pituitary Adenylate Cyclase-activating Polypeptide (PACAP)
Highly Cited
1997
Highly Cited
1997
In Vitro Characterization of the Novel Proprotein Convertase PC7*
Biochemical and enzymatic characterization of the novel proprotein convertase rat PC7 (rPC7) was carried out using vaccinia virus… 
Highly Cited
1996
Highly Cited
1996
A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas.
A new member of the proprotein convertase gene family (LPC) has been identified at a chromosome translocation breakpoint… 
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