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A conditional tissue-specific transgene expression system using inducible GAL4
In Drosophila, the most widely used system for generating spatially restricted transgene expression is based on the yeast GAL4 protein and its target upstream activating sequence (UAS). To permitExpand
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Stereotypic morphology of glutamatergic synapses on identified muscle cells of Drosophila larvae
The distribution and morphology of glutamatergic synapses on Drosophila bodywall muscle fibers were examined at the single-synapse level using immunocytochemistry and electrophysiology. We find thatExpand
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A Systematic Nomenclature for the Insect Brain
Despite the importance of the insect nervous system for functional and developmental neuroscience, descriptions of insect brains have suffered from a lack of uniform nomenclature. AmbiguousExpand
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Targeted Attenuation of Electrical Activity in Drosophila Using a Genetically Modified K+ Channel
We describe here a general technique for the graded inhibition of cellular excitability in vivo. Inhibition is accomplished by expressing a genetically modified Shaker K(+) channel (termed the EKOExpand
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Fray, a Drosophila Serine/Threonine Kinase Homologous to Mammalian PASK, Is Required for Axonal Ensheathment
Fray is a serine/threonine kinase expressed by the peripheral glia of Drosophila, whose function is required for normal axonal ensheathment. Null fray mutants die early in larval development and haveExpand
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The drosophila neuromuscular junction: a model system for studying synaptic development and function.
The Drosophila neuromuscular junction has attracted widespread attention as an excellent model system for studying the cellular and molecular mechanisms of synaptic development and neurotransmission.Expand
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Identified motor terminals in Drosophila larvae show distinct differences in morphology and physiology.
In Drosophila, the type I motor terminals innervating the larval ventral longitudinal muscle fibers 6 and 7 have been the most popular preparation for combining synaptic studies with genetics. WeExpand
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Dissection of synaptic excitability phenotypes by using a dominant-negative Shaker K+ channel subunit.
During nervous system development, synapses undergo morphological change as a function of electrical activity. In Drosophila, enhanced activity results in the expansion of larval neuromuscularExpand
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Quantitative staging of embryonic development of the grasshopper, Schistocerca nitens.
During development of the grasshopper embryo, it is feasible to examine the structure, pharmacology, and physiology of uniquely identified cells. These experiments require a fast, accurate stagingExpand
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Identification of the neuropeptide transmitter proctolin in Drosophila larvae: characterization of muscle fiber-specific neuromuscular endings
The cellular localization of the peptide neurotransmitter proctolin was determined for larvae of the fruitfly Drosophila melanogaster. Proctolin was recovered from the CNS, hindgut, and segmentalExpand
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