Proprotein Convertase 1

Known as: PC3, Endoprotease, PC1, Prohormone Convertase, PC1 
A CALCIUM-dependent endopeptidase that has specificity for cleavage at ARGININE that is near paired basic residues. It cleaves a variety of… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1972-2017
0204019722017

Papers overview

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Highly Cited
2008
Highly Cited
2008
Resistance to cell death is a hallmark of cancer. Autophagy is a survival mechanism activated in response to nutrient deprivation… (More)
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Highly Cited
2008
Highly Cited
2008
Polycystin-1 (PC1), the product of the PKD1 gene mutated in the majority of autosomal dominant polycystic kidney disease (ADPKD… (More)
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Highly Cited
2005
Highly Cited
2005
The invasive ability of tumor cells plays a key role in prostate cancer metastasis and is a major cause of treatment failure… (More)
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Highly Cited
2005
Highly Cited
2005
Prostate cancer is the most common invasive malignancy and the second leading cause of cancer-related deaths among U.S. males… (More)
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Highly Cited
2005
Highly Cited
2005
In eukaryotes, many secreted proteins and peptide hormones are excised from larger precursors by calcium-dependent serine… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND The gene for the renal phosphate wasting disorder autosomal-dominant hypophosphatemic rickets (ADHR) is FGF23, which… (More)
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Highly Cited
2000
Highly Cited
2000
The p53-inducible gene PC3 (TIS21, BTG2) is endowed with antiproliferative activity. Here we report that expression of PC3 in… (More)
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Highly Cited
1997
Highly Cited
1997
The prohormone convertase SPC2 (PC2) participates in the processing of proinsulin, proglucagon, and a variety of other… (More)
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Highly Cited
1997
Highly Cited
1997
Interleukin (IL)-6 plays a significant role in genitourinary carcinomas. The present study was conducted to define the role of IL… (More)
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Highly Cited
1991
Highly Cited
1991
PC3 is an immediate early gene induced by nerve growth factor in PC12 cells, a cell line derived from a tumor of the adrenal… (More)
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