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PCSK1 protein, human

Known as: proprotein convertase subtilisin-kexin type 1, human, Proprotein Convertase Subtilisin/Kexin-Type 1, Neuroendocrine Convertase 1 
Neuroendocrine convertase 1 (753 aa, ~84 kDa) is encoded by the human PCSK1 gene. This protein plays a role in the proteolytic activation of protein… 
National Institutes of Health

Related topics

Related topics

12 relations
EndopeptidasesEnzyme GeneHydrolysisIntegral Membrane Proteins

Broader (1)

Proprotein Convertase 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
Prohormone-Convertase 1 Processing Enhances Post-Golgi Sorting of Prothyrotropin-releasing Hormone-derived Peptides*
Rat prothyrotropin-releasing hormone (pro-TRH) is endoproteolyzed within the regulated secretory pathway of neuroendocrine cells… 
2002
2002
Functional Characterization of ProSAAS
Prohormone convertases (PC) 1 and 2, enzymes found primarily in neuroendocrine tissues, are thought to mediate the proteolytic… 
2000
2000
Regional and cellular localization of the neuroendocrine prohormone convertases PC1 and PC2 in the rat central nervous system
PC1 and PC2 are two major enzymes involved in the processing of protein precursors directed to the regulated secretory pathway… 
1998
1998
PC5-A-mediated Processing of Pro-neurotensin in Early Compartments of the Regulated Secretory Pathway of PC5-transfected PC12 Cells*
Among the members of the proprotein convertase (PC) family, PC1 and PC2 have well established roles as prohormone convertases… 
1997
1997
Immunocytochemical localization of prohormone convertases PC1 and PC2 in the anuran pituitary gland: subcellular localization in corticotrope and melanotrope cells
Abstract.Specific antisera against mammalian prohormone convertases PC1 and PC2 have been used to examine, light… 
Highly Cited
1995
Highly Cited
1995
Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells.
Endoproteolytic cleavage of pairs of basic amino acids is the key mechanism in the specific processing of precursor hormone… 
1995
1995
Mutational Analysis of PC1 (SPC3) in PC12 Cells
The proteinase mPC1, a neuroendocrine member of the mammalian family of subtilisin-like enzymes, has previously been shown to be… 
1995
1995
The role of prohormone convertases PC1 (PC3) and PC2 in the cell-specific processing of proglucagon.
To elucidate the mechanism of the differential processing of proglucagon, we analyzed the processing products of proglucagon in… 
Highly Cited
1994
Highly Cited
1994
Developmental expression of the prohormone convertases PC1 and PC2 in mouse pancreatic islets.
The immunocytochemical distribution and messenger RNA expression of the prohormone convertases PC1 and PC2 involved in the… 
Highly Cited
1993
Highly Cited
1993
Heterologous processing of prosomatostatin in constitutive and regulated secretory pathways. Putative role of the endoproteases furin, PC1, and PC2.
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